Relationship between Galectin-3,LCN2,Sema3A Levels in Gingival Crevicular Fluid and Periodontal Indexes and Disease Severity of Chronic Periodontitis Patients
Objective:To investigate the relationship between the Galactocondensin-3(Galectin-3),Lipid-carrying protein 2(LCN2),Semaphorin 3A(Sema3A)levels in gingival crevicular fluid(GCF)and periodontal indexes and disease severity of chronic peri-odontitis patients.Methods:142 chronic periodontitis patients who were admitted to periodontology department of our hospital from July 2021 to July 2023 were selected as the observation group,and 90 healthy volunteers who were revisited in the periodontal department of our hospital during the same period were included as the control group.The Galectin-3,LCN2 and Sema3A levels in GCF were com-pared between control group and observation group.Chronic periodontitis patients were divided into mild to moderate periodontitis group(n=83)and severe periodontitis group(n=59)according to the disease severity.The Galectin-3,LCN2,Sema3A levels in GCF and periodontal indexes were compared between mild to moderate periodontitis group and severe periodontitis group.The correlation be-tween Galectin-3,LCN2,Sema3A levels in GCF and periodontal indexes were analyzed by Pearson correlation test.Results:The Galectin-3 and LCN2 levels in GCF in observation group were higher than those in control group,and the Sema3A level in GCF was lower than that in control group(P＜0.05).The Galectin-3,LCN2 levels in GCF,gingival index(GI),periodontal pocket depth(PD)and attachment loss(AL)in severe periodontitis group were higher than those in mild to moderate periodontitis group,and the Sema3A level in GCF was lower than that in mild to moderate periodontitis group(P＜0.05).The Galectin-3 and LCN2 levels in GCF were positively correlated with GI,PD and AL,and the Sema3A level in GCF was negatively correlated with GI,PD and AL(P＜0.05).Conclusion:The Galectin-3 and LCN2 levels in GCF of chronic periodontitis patients are increased,and the Sema3A level is decreased,which are related to periodontal indexes and disease severity.
Gingival crevicular fluidGalactocondensin-3Lipid-carrying protein 2Semaphorin 3AChronic periodontitisPeri-odontal indexesDisease severity
NETL
NSTL
万方数据
