Clinical Study on the Expression of Serum miR-202 and miR-34a and Nosocomial Infection in Patients with Primary Liver Cancer after TACE
Objective:To analyze the relationship between serum microRNA(miR)-202,miR-34a expression and nosocomial in-fection in patients with primary liver cancer(PLC)after transcatheter arterial chemoembolization(TACE).Methods:975 patients with PLC who underwent TACE were selected.Patients were divided into infection group(n=80)and uninfected group(n=895)according to whether nosocomial infection occurred after TACE,the relative expression levels of serum miR-202 and miR-34a and clinical data were compared between two groups,the influencing factors were analyzed by multivariate Logistic regression model,the value of were ana-lyzed by receiver operating characteristic(ROC)curve.Results:The age ≥60 years old,diabetes mellitus,ascites,interventional opera-tion time≥120 min,and non-prophylactic use of antibiotics were risk factors for nosocomial infection in patients with PLC after TACE(P＜0.05),the increase in the relative expression of serum miR-202 and miR-34a were protective factor(P＜0.05).The combined predic-tion of serum miR-202 and miR-34a for postoperative nosocomial infection in PLC patients with TACE was higher than that of single prediction.Conclusion:The expression of serum miR-202 and miR-34a in patients with PLC after TACE are low,and their combination can effectively predict the occurrence of nosocomial infection after TACE.
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