Evaluation of Left Ventricular Longitudinal Systolic Function in Patients with Thyroid Dysfunction by 3D-STI and its Relationship with Cardiac Function Indexes and Serum Myocardial Injury Markers
Objective:To investigate the evaluation of left ventricular longitudinal systolic function in patients with thyroid dys-function by three-dimensional speckle tracking imaging(3D-STI)and its relationship with cardiac function indexes and serum myocar-dial injury markers.Methods:120 patients with abnormal thyroid function(study group)and 80 patients with normal thyroid function(control group)were selected,the parameters of global circumferential strain(GCS),global longitudinal strain(GLS),left ventricular sys-tolic global area strain(GAS),left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic diameter(LVEDS)and left ventricular end-diastolic diameter(LVEDD)were compared between two groups,the levels of serum troponin 1(cTn1),creatine kinase(CK)and CK isoenzyme(CK-MB)were detected in two groups.The correlation between 3D-STI parameters and conventional ultrasound parameters and the levels of serum cTn1,CK and CK-MB was analyzed by Pearson cor-relation analysis.Results:There was no significant difference in LVEDD,LVEDS,LVEDV and LVEF between study group and control group(P＞0.05),the absolute values of GAS,GLS and GCS in study group were lower than those in control group,The levels of cTn1,CK and CK-MB were higher than those in control group(P＜0.05).The absolute values of GAS,GLS and GCS in study group were nega-tively correlated with the levels of serum cTn1,CK and CK-MB(P＜0.05),but not with LVEDD,LVEDS,LVEDV and LVEF(P＞0.05).Conclusion:3D-STI parameters GAS,GLS and GCS are decrease in patients with thyroid dysfunction,and the levels of serum cTn1,CK and CK-MB are increase,3D-STI parameters can effectively assess the longitudinal function of the left ventricular contraction in patients with abnormal thyroid function.
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