血清BDNF、IGF-1及CysC水平与帕金森病患者自主神经功能障碍的关系研究
Study on the Relationship between Serum BDNF,IGF-1 and CysC Levels and Autonomic Nerve Dysfunction in Patients with Parkinson's Disease
刘丽娟 1康涛 1王卫婵 1卫婧雅 1杜芳1
作者信息
- 1. 空军军医大学第一附属医院神经内科 陕西西安 710000
- 折叠
摘要
目的:研究血清脑源性神经营养因子(BDNF)、胰岛素样生长因子(IGF)-1及胱抑素C(CysC)水平与帕金森病(PD)患者自主神经功能障碍的关系.方法:188例PD患者根据是否发生自主神经功能障碍分为自主神经功能障碍组(n=63)、非自主神经功能障碍组(n=125).另选取健康志愿者140例为对照组.比较三组BDNF、IGF-1水平.采用多因素Logistic回归分析影响因素.结果:对照组、非自主神经功能障碍组、自主神经功能障碍组BDNF、IGF-1水平依次下降,CysC水平依次升高(P＜0.05).血清BDNF、IGF-1低水平、血清CysC高水平、SSR异常、H-Y分期2.5～4期是PD患者自主神经功能障碍的危险因素(P＜0.05).结论:血清BDNF、IGF-1低水平及CysC高水平促进PD患者自主神经功能障碍的发生发展.
Abstract
Objective:To study the relationship between serum brain-derived neurotrophic factor(BDNF),insulin-like growth factor(IGF)-1 and cystatin C(CysC)levels and autonomic nerve dysfunction in patients with Parkinson's disease(PD).Methods:188 PD patients were divided into autonomic nerve dysfunction group(n=63)and non-autonomic nerve dysfunction group(n=125)according to the occurrence of autonomic nerve dysfunction,and 140 healthy volunteers were selected as the control group.the levels of BDNF and IGF-1 among three groups were compared.The influencing factors was analyzed by multivariate Logistic regression analysis.Results:The BDNF,IGF-1 levels in control group,non-autonomic nerve dysfunction group and autonomic nerve dysfunction group decreased in turn,and the CysC level increased in turn(P＜0.05).Low serum BDNF,IGF-1 levels,high serum CysC level,abnormal SSR,and H-Y stage 2.5～4 were risk factors for autonomic dysfunction in PD patients(P＜0.05).Conclusion:The low serum BDNF,IGF-1 levels and high CysC level promote the occurrence and development of autonomic nerve dysfunction in PD patients.
关键词
脑源性神经营养因子/胰岛素样生长因子-1/胱抑素C/帕金森病/自主神经功能障碍Key words
Brain-derived neurotrophic factor/Insulin-like growth factor/Cystatin C/Parkinson's disease/Autonomic nerve dys-function引用本文复制引用
出版年
2024
NETL
NSTL
万方数据