Study on the Relationship between Serum BDNF,IGF-1 and CysC Levels and Autonomic Nerve Dysfunction in Patients with Parkinson's Disease
Objective:To study the relationship between serum brain-derived neurotrophic factor(BDNF),insulin-like growth factor(IGF)-1 and cystatin C(CysC)levels and autonomic nerve dysfunction in patients with Parkinson's disease(PD).Methods:188 PD patients were divided into autonomic nerve dysfunction group(n=63)and non-autonomic nerve dysfunction group(n=125)according to the occurrence of autonomic nerve dysfunction,and 140 healthy volunteers were selected as the control group.the levels of BDNF and IGF-1 among three groups were compared.The influencing factors was analyzed by multivariate Logistic regression analysis.Results:The BDNF,IGF-1 levels in control group,non-autonomic nerve dysfunction group and autonomic nerve dysfunction group decreased in turn,and the CysC level increased in turn(P＜0.05).Low serum BDNF,IGF-1 levels,high serum CysC level,abnormal SSR,and H-Y stage 2.5～4 were risk factors for autonomic dysfunction in PD patients(P＜0.05).Conclusion:The low serum BDNF,IGF-1 levels and high CysC level promote the occurrence and development of autonomic nerve dysfunction in PD patients.
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