Value of PDUS Quantitative Grading and SWE in the Qualitative Diagnosis of Thyroid Nodules and Their Correlation with Histopathological Structure
Objective:To investigate the diagnostic value of power doppler ultrasound(PDUS)semi quantitative grading and shear wave elastography(SWE)in the qualitative diagnosis of thyroid nodules,and to explore its correlation with histopathological struc-ture.Methods:A total of 170 patients with thyroid nodules underwent PDUS and SWE examinations,the pathological results were used as the gold standard to analyze the qualitative diagnostic efficacy of PDUS semi quantitative grading,SWE alone and combined examina-tion for benign and malignant thyroid nodules.According to the distribution of parenchyma and stroma in postoperative pathological tis-sue structure,the relationship between PDUS semi quantitative grading,SWE results and histopathological structure was analyzed by multivariate Logistic regression analysis.Results:The Kappa value,sensitivity,specificity and accuracy of PDUS combined with SWE in the diagnosis of benign and malignant thyroid nodules were significantly higher than those of the two methods alone.Multivariate logistic regression analysis showed that the correlation between histological features and PDUS semi quantitative grading was as follows:extensive fibrosis＞papillary structure＞microfollicular structure,and the correlation between various histological features and SWE was as follows:extensive fibrosis＞papillary structure＞inflammatory cell infiltration＞local fibrosis.Conclusion:PDUS semi quantitative grading com-bined with SWE can significantly improve the qualitative diagnostic value of benign and malignant thyroid nodules,and extensive inter-stitial fibrosis is the most significant histopathological factor affecting the detection of thyroid nodules by PDUS and SWE.
Power Doppler ultrasoundSemi quantitative gradingShear wave elastographyThyroid nodulesQualitative diagnosisHistopathological structureCorrelation
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