Analysis of Changes in Serum OPN and HGF Levels and Their Relationship with Prognosis in Children with Acute Lymphoblastic Leukemia of Different Risk Classification
Objective:To study the changes of serum osteopontin(OPN)and hepatocyte growth factor(HGF)in children with dif-ferent risk classification of acute lymphoblastic leukemia(ALL)and their relationship with prognosis.Methods:160 children with ALL were selected.Patients were divided into low risk(LR)group(n=74),intermediate risk(IR)group(n=55)and high risk(HR)group(n=31)according to the risk classification.The levels of serum OPN and HGF in children with different risk classification were com-pared.Standardized treatment was carried out according to different risk degrees,follow-up 1 year,children were divided into poor prog-nosis group and good prognosis group according to their prognosis.The influencing factors of poor prognosis in children with ALL were analyzed by multivariate Logistic regression analysis.Results:The levels of serum OPN and HGF in IR group and HR group were higher than those in LR group,and those in HR group were higher than those in IR group(P＜0.05).Follow-up 1 year,the incidence of poor prog-nosis in children with ALL was 27.50％.The serum levels of OPN and HGF in poor prognosis group were higher than those in good prognosis group(P＜0.05).Multivariate Logistic regression analysis showed that,high risk classification,elevated OPN and HGF were risk factors for poor prognosis in children with ALL(P＜0.05).Conclusion:The levels of serum OPN and HGF in children with ALL were increased,which are related to the risk classification.High risk classification,elevated OPN and HGF are risk factors for poor prognosis in children with ALL.
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