Effects of Sufentanil Combined with Esketamine on Postoperative Pain,Immune Inflammatory Response,Anxiety and Depression in Patients Undergoing Thoracoscopic Radical Resection of Lung Cancer
Objective:To observe the effects of sufentanil and esketamine combined anesthesia on postoperative immune inflam-matory response,analgesic effect,anxiety and depression in patients undergoing thoracoscopic radical resection of lung cancer.Methods:120 patients undergoing thoracoscopic radical resection of lung cancer were divided into control group(60 cases,sufentanil treatment)and study group(60 cases,sufentanil and esketamine combined anesthesia)by random number table method.Analgesia,sedation score,cellular immune function index,inflammatory factors,anxiety and depression score and incidence of adverse reactions were compared between two groups.Results:The Visual Simulation of Pain(VAS)scores in study group were lower than those in control group at the same time point 24 h,48 h and 72 h after operation.Ramsay sedation score was higher than that in control group at the same time point(P＜0.05).CD8+in study group was lower than that in control group 24 h after operation,CD4+/CD84,CD4+and CD3+were higher than those in control group,and tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)were lower than those in control group(P＜0.05).The SAS and SDS scores in study group were lower than those in control group 7 days after operation(P＜0.05).There was no difference in the incidence of adverse reactions between two groups(P＞0.05).Conclusion:Patients with thoracoscopic radical resection of lung cancer after sufunthanil and esketamine,which can play a good analgesic and sedative effect,improve immune function,control inflammation,reduce anxiety and depression,and good safety.
EsketamineSufentanilThoracoscopic radical resection of lung cancerAnalgesic effectImmune inflammatoryAnxi-ety and depression
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