Correlation Analysis of miR-27a,miR-141 and PI3K/AKT Signaling Pathway in Peripheral Blood Lymphocytes of Obese Patients with Polycystic Ovary Syndrome
Objective:To investigate the correlation between microRNA(miR)-27a,miR-141 and phosphatidylinositol 3 kinase(PI3K)/protein kinase B(AKT)signa/ing pathway in peripheral blood lymphocytes of obese patients with polycystic ovary syndrome(PCOS).Methods:110 PCOS patients were selected,and patients were divided into non-obese group(40 cases)and obese group(70 cases)according to body mass index(BMI).The levels of miR-27a,miR-141 expression in peripheral blood lymphocytes and PI3K mRNA,AKT mRNA in peripheral blood were detected,and the correlation were analyzed by Pearson method.Results:Compared with non-obese group,the levels of miR-27a and miR-141 expression in peripheral blood lymphocytes of PCOS patients in obese group were higher,the expression levels of PI3K mRNA and AKT mRNA in peripheral blood were lower(P＜0.05).The levels of miR-27a and miR-141 expression in peripheral blood lymphocytes of PCOS patients was negatively correlated with the expression of PI3K mRNA and AKT mRNA in peripheral blood(P＜0.05).Conclusion:The levels of miR-27a and miR-141 expression in peripheral blood lymphocytes of obese PCOS patients increased,and the levels of PI3K mRNA and AKT mRNA expression in peripheral blood decreased.The high expression of miR-27a and miR-141 are related to the inhibition of PI3K/Akt signaling pathway in PCOS patients.
Obese type of polycystic ovary syndromemiR-27amiR-141PI3K/Akt signaling pathway
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