Analysis of the Significance of LncRNA UNC5B-AS1,GSTP1 and miR-372 Expression in Non-small Cell Lung Cancer Tissues
Objective:The expression and significance of lncRNA UNC5B-AS1,GSTP1 and miR-372 in NSCLC tissues were analyzed.Methods:Lung cancer tissues of 90 NSCLC patients admitted to our hospital from 2019.1 to 2023.12 were selected as the experimental group,and normal lung tissues of 47 patients with benign lung diseases were selected as the control group.The experimental group was divided into three groups according to the degree of differentiation:low,medium and high differentiation.Univariate and multifactor regression analysis were used to compare the levels of lncRNA UNC5B-AS1,GSTP1 and miR-372 among all groups.Results:The levels of lncRNA UNC5B-AS1 and GSTP1 in the experimental group were higher than the control group,and the expression of miR-372 was lower than that in the control group(P＜0.05).With the increase of differentiation degree,the expressions of lncRNA UNC5B-AS1 and GSTP1 were decreased,and the expression of miR-372 was increased(P＜0.05).Logistic regression analysis showed that lncRNA UNC5B-AS1 and GSTP1 were risk factors for NSCLC,and miR-372 was protective factor for NSCLC(P＜0.05).The AUC value of NSCLC predicted by the combined test was higher than that by the single test(Z=3.659,3.349,3.981,P＜0.05).Conclusions:lncRNA UNC5B-AS1 and GSTP1 are highly expressed in NSCLC tissues,and miR-372 is lowly expressed in NSCLC tissues,which can reflect the differentiation degree of NSCLC.Combined detection has certain clinical value in predicting NSCLC.
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