Explore the Efficacy and Mechanism of Jiawei Buzhong Yiqi Decoction Combined with Quadruple Therapy in the Treatment of Hp Positive Chronic Atrophic Gastritis Based on TLR4/NF-κB Signaling Pathway
Objective:Base on Toll-like variant 4(TLR4)/nuclear factor-KB(NF-κB)signaling pathway to explore the efficacy and mechanism of jiawei buzhong yiqi decoction combine with quadruple therapy in the treatment of Helicobacter pylori(Hp)positive chronic atrophic gastritis(CAG).Methods:138 Hp positive CAG patients were randomly divided into control group(treated with quadru-ple therapy,69 cases)and study group(treated with jiawei buzhong yiqi decoction combined with quadruple therapy,69 cases).The tra-ditional chinese medicine syndrome points,Hp eradication rate,serum gastrointestinal hormones,serum pepsinogen(PG)and TLR4/NF-κB signaling pathway related indicators were compared between two groups.Results:Hp eradication rate in study group was higher than that in control group after treatment,and the main symptoms,secondary symptoms and total scores were lower than those in control group(P＜0.05).After treatment,Gastrin(GAS),PGⅡ in study group was lower than that in control group and motilin(MTL),PGI was higher than that in control group(P＜0.05).TLR4 messenger RNA(mRNA)and NF-κB mRNA expression in study group were lower than those in control group after treatment(P＜0.05).Conclusion:Jiawei buzhong yiqi decoction combine with quadruple therapy in the treatment of Hp positive CAG patients,which can effectively improve clinical symptoms and improve Hp eradication rate,regulate serum gastrointestinal hormones and PG levels.The mechanism of efficacy may be related to the regulation of TLR4/NF-κB signaling pathway.
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