Relationship between TREM-1 and MCP-1 in Cerebrospinal Fluid and the Outcome of Surgical Treatment in Patients with Aneurysmal Subarachnoid Hemorrhage
Objective:To investigate the relationship between triggering receptor expressed on myeloid cells-1(TREM-1)and monocyte chemoattractant protein-1(MCP-1)in cerebrospinal fluid and the outcome of surgical treatment in patients with aneurysmal subarachnoid hemorrhage(aS AH).Methods:294 patients with aS AH were selected,the levels of TREM-1 and MCP-1 in cerebrospinal fluid were detected before operation.3 months after discharge,patient outcomes were assessed using the modified Rankin scale(mRS),and patients were divided into poor outcome group(103 cases)and good outcome group(191 cases)according to this.The factors affect-ing the poor outcome after aSAH were analyzed by multivariate logistic regression analysis.Results:The levels of TREM-1 and MCP-1 in cerebrospinal fluid in poor outcome group were higher than those in good outcome group(P＜0.05).Hunt-Hess grade Ⅲ～Ⅳ,delayed cerebral ischemia,increased TREM-1 and MCP-1 were risk factors for poor outcome after aSAH(P＜0.05).Conclusion:The increase of serum TREM-1 and MCP-1 levels in patients with poor outcome after aSAH are risk factor for poor outcome after aSAH.
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