Relationship between Serum Testosterone,PON-1,PKM2 and Clinicopathological Features and Prognosis of Endometrial Cancer Patients
Objective:To investigate the relationship between serum testosterone(T),paraoxonase-1(PON-1),pyruvate kinase M2(PKM2)and clinicopathological features and prognosis of endometrial carcinoma(EC)patients.Methods:The clinical data of 120 EC patients were collected.The relationship between serum T,PON-1,PKM2 and clinicopathological features of EC patients was ana-lyzed.The 3-year overall survival(OS)was analyzed by drawn K-M survival curve.The prognostic factors of EC patients were analyzed by Cox proportional hazard model.Results:The levels of serum T and PKM2 in patients with myometrial invasion ≥ 1/2,lymph node metastasis,ascites or tumor cell flushing fluid positive and International Federation of Gynecology and Obstetrics(FIGO)stage Ⅲ-Ⅳwere higher than those in patients with myometrial invasion＜l/2,no lymph node metastasis,ascites or tumor cell flushing fluid negative and FIGO stage Ⅰ-Ⅱ,while PON-1 was relatively lower(P＜0.05).The 3-year OS of EC patients with high PON-1 level was higher than that of EC patients with high serum T and PKM2 levels,and the low level of PON-1 was higher(P＜0.05).Cox proportional hazard model analysis showed that,ascites or tumor cell flushing fluid positive,high serum T level,low PON-1 level and high PKM2 level were risk factors for poor prognosis in EC patients.Conclusion:High levels of serum T,PKM2,and low levels of PON-1 are associate with my-ometrial invasion,lymph node metastasis,ascites or tumor cell flushing fluid positive,FIGO stage Ⅲ-Ⅳ and poor prognosis in EC pa-tients,risk factors for poor prognosis in EC patients include ascites or tumor cell flushing fluid positive,high levels of serum T,low levels of PON-1 and high levels of PKM2.
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