摘要
目的:探讨血清睾酮(T)、对氧磷酶-1(PON-1)、丙酮酸激酶M2(PKM2)与子宫内膜癌(EC)患者临床病理特征和预后的关系.方法:收集120例EC患者的临床资料,分析血清T、PON-1、PKM2与EC患者临床病理特征的关系;绘制K-M生存曲线分析3年总生存率(OS);Cox比例风险模型分析影响因素.结果:肌层浸润≥ 1/2、有淋巴结转移、腹腔积液亦或是肿瘤细胞冲洗液阳性、国际妇产科联盟(FIGO)分期为Ⅲ-Ⅳ期的血清T及PKM2水平较肌层浸润＜1/2、无淋巴结转移、腹腔积液亦或是肿瘤细胞冲洗液阴性、FIGO分期为Ⅰ-Ⅱ期更高,而PON-1则相对更低(P＜0.05).EC患者血清T及PKM2低水平,PON-1高水平的3年OS较血清T及PKM2高水平,PON-1低水平更高(P＜0.05).Cox比例风险模型分析显示,腹腔积液亦或是肿瘤细胞冲洗液阳性、血清T高水平、PON-1低水平及PKM2高水平是EC患者不良预后的危险因素.结论:血清T、PKM2高水平,PON-1低水平与EC患者的肌层浸润、淋巴结转移、腹腔积液亦或是肿瘤细胞冲洗液阳性、FIGO分期Ⅲ-Ⅳ期及不良预后有关,EC患者不良预后的危险因素包括腹腔积液亦或是肿瘤细胞冲洗液阳性、血清T高水平、PON-1低水平及PKM2高水平.
Abstract
Objective:To investigate the relationship between serum testosterone(T),paraoxonase-1(PON-1),pyruvate kinase M2(PKM2)and clinicopathological features and prognosis of endometrial carcinoma(EC)patients.Methods:The clinical data of 120 EC patients were collected.The relationship between serum T,PON-1,PKM2 and clinicopathological features of EC patients was ana-lyzed.The 3-year overall survival(OS)was analyzed by drawn K-M survival curve.The prognostic factors of EC patients were analyzed by Cox proportional hazard model.Results:The levels of serum T and PKM2 in patients with myometrial invasion ≥ 1/2,lymph node metastasis,ascites or tumor cell flushing fluid positive and International Federation of Gynecology and Obstetrics(FIGO)stage Ⅲ-Ⅳwere higher than those in patients with myometrial invasion＜l/2,no lymph node metastasis,ascites or tumor cell flushing fluid negative and FIGO stage Ⅰ-Ⅱ,while PON-1 was relatively lower(P＜0.05).The 3-year OS of EC patients with high PON-1 level was higher than that of EC patients with high serum T and PKM2 levels,and the low level of PON-1 was higher(P＜0.05).Cox proportional hazard model analysis showed that,ascites or tumor cell flushing fluid positive,high serum T level,low PON-1 level and high PKM2 level were risk factors for poor prognosis in EC patients.Conclusion:High levels of serum T,PKM2,and low levels of PON-1 are associate with my-ometrial invasion,lymph node metastasis,ascites or tumor cell flushing fluid positive,FIGO stage Ⅲ-Ⅳ and poor prognosis in EC pa-tients,risk factors for poor prognosis in EC patients include ascites or tumor cell flushing fluid positive,high levels of serum T,low levels of PON-1 and high levels of PKM2.
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