首页|紫叶丹胶囊与富马酸丙酚替诺福韦片联合治疗对慢性乙型肝炎患者肝功能、肝纤维化和血清M-CSF、CTGF、CHI3L1的影响

紫叶丹胶囊与富马酸丙酚替诺福韦片联合治疗对慢性乙型肝炎患者肝功能、肝纤维化和血清M-CSF、CTGF、CHI3L1的影响

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目的:观察紫叶丹胶囊与富马酸丙酚替诺福韦片联合治疗对慢性乙型肝炎(CHB)患者肝功能、肝纤维化和血清巨噬细胞集落刺激因子(M-CSF)、结缔组织生长因子(CTGF)、壳多糖酶3样蛋白1(CHI3L1)的影响.方法:采用随机数字表法将138例CHB患者分为对照组(富马酸丙酚替诺福韦片治疗)、研究组(对照组基础上与紫叶丹胶囊联合治疗),各为69例.对比两组疗效、肝功能指标、血清M-CSF、CTGF、CHI3L1水平、肝纤维化指标和不良反应发生率.结果:研究组的临床总有效率高于对照组(P＜0.05).研究组治疗后丙氨酸氨基转移酶(ALT)、M-CSF、天门冬氨酸氨基转移酶(AST)、Ⅲ型前胶原(PC-Ⅲ)、CTGF、透明质酸(HA)、总胆红素(TBiL)、Ⅳ型胶原(Ⅳ-C)、CHI3L1、层黏蛋白(LN)低于对照组(P＜0.05).两组不良反应发生率对比组间未见差异(P＞0.05).结论:采用紫叶丹胶囊和富马酸丙酚替诺福韦片联合治疗CHB患者,可有效改善其肝功能、肝纤维化程度和血清M-CSF、CTGF、CHI3L1 水平.
Effects of Combined Treatment of Ziyedan Capsules and Tenofovir Alafenamide Fumarate Tablets on Liver Function,Liver Fibrosis and Serum M-CSF,CTGF and CHI3L1 in Patients with Chronic Hepatitis B
Objective:To observe the effects of combined treatment of ziyedan capsules and tenofovir alafenamide fumarate tablets on liver function,liver fibrosis and serum macrophage colony-stimulating factor(M-CSF),connective tissue growth factor(CTGF)and chitinase 3-like protein 1(CHI3L1)in patients with chronic hepatitis B(CHB).Methods:138 CHB patients were divided into control group(treated with tenofovir alafenamide fumarate tablets)and study group(combined treatment with ziyedan capsules on the basis of control group)by random number table method,69 cases in each group.The efficacy,liver function indexes,serum M-CSF,CTGF,CHI3L1 levels,liver fibrosis indexes and incidence of adverse reactions were compared between two groups.Results:The total clinical effective rate in study group was higher than that in control group(P＜0.05).Alanine aminotransferase(ALT),M-CSF,aspartate amino-transferase(AST),type Ⅲ procollagen(PC-Ⅲ),CTGF,hyaluronic acid(HA),total bilirubin(TBiL),type Ⅳ collagen(Ⅳ-C),CHI3L1 and laminin(LN)in study group were lower than those in control group after treatment(P＜0.05).There was no difference in the inci-dence of adverse reactions between two groups(P＞0.05).Conclusion:The combination of ziyedan capsules and tenofovir alafenamide fumarate tablets in the treatment of CHB patients,which can effectively improve the liver function,the degree of liver fibrosis,the levels of serum M-CSF,CTGF and CHI3L1.

Ziyedan capsulesTenofovir alafenamide fumarate tabletsChronic hepatitis BLiver functionLiver fibrosisM-CSFCTGFCHI3L1

蒋雨桐、谢学建、王燕、万海军、高茗

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中国人民解放军东部战区总医院药剂科 江苏南京 210000

中国人民解放军东部战区总医院消化科 江苏南京 210000

紫叶丹胶囊 富马酸丙酚替诺福韦片 慢性乙型肝炎 肝功能 肝纤维化 M-CSF CTGF CHI3L1

2024

10.13241/j.cnki.pmb.2024.22.032

现代生物医学进展
黑龙江省森工总医院 哈尔滨医科大学附属第四医院

现代生物医学进展

CSTPCD
影响因子：0.755
ISSN：1673-6273
年,卷(期)：2024.24(22)