Effect of Banxia Xiexin Decoction on MAPK/ERK Signaling Pathway in Patients with Hp Positive Chronic Atrophic Gastritis
Objective:To observe the effect of banxia xiexin decoction on mitogen-activated protein kinase(MAPK)/extracellular signal-regulated kinase(ERK)signaling pathway in patients with Helicobacter pylori(Hp)positive chronic atrophic gastritis(CAG).Methods:96 Hp positive CAG patients were randomly divided into control group(treated with conventional quadruple therapy,48 cases)and observation group(treated with banxia xiexin decoction combined with conventional quadruple,48 cases).The efficacy,Hp eradica-tion rate,traditional chinese medicine syndrome points,pepsinogen(PG)and MAPK/ERK signaling pathway related indicators were compared between two groups.Results:The total clinical effective rate and Hp eradication rate in observation group were higher than that of the control group,respectively(P＜0.05).After treatment,compared with control group,the main symptoms,secondary symptoms,total scores,PGⅡ,the expression of MEK1 messenger ribonucleic acid(mRNA),MEK2 mRNA,ERK1 mRNA,and ERK2 mRNA in observation group were lower,and PGI was higher(P＜0.05).Conclusion:Banxia xiexin decoction in the treatment of Hp positive CAG patients,which can improve the clinical treatment effect,improve the clinical symptoms and PG level,and regulate the MAPK/ERK sig-naling pathway in peripheral blood.
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