Effects of Aspergillus Oryzae Pancreatin Tablets on Intestinal Flora,Gastrointestinal Function and Serum GLP-1 and PYY Levels in Patients with Cirrhosis-Related Dyspepsia
Objective:To investigate the effects of aspergillus oryzae pancreatin tablets on intestinal flora,gastrointestinal function and serum glucagon-like peptide-1(GLP-1)and casein peptide(PYY)levels in patients with cirrhosis-related dyspepsia.Methods:According to the random number table method,129 patients with liver cirrhosis-related dyspepsia who were treated in our hospital from March 2021 to December 2023 were divided into control group(routine treatment of liver cirrhosis,n=64)and experimental group(treated with aspergillus oryzae trypsin tablets on the basis of control group,n=65).The changes of dyspepsia symptom score,intestinal flora index,gastrointestinal function index,serum GLP-1 and PYY levels and quality of life were compared between two groups.Results:The scores of dyspepsia symptoms,the number of enterococcus,enterobacter,the levels of GLP-1,PYY and NDI score in experimental group were lower than that in control group 4 weeks after treatment,and the number of bifidobacteria,lactobacilli,the gastric emptying rate,gastric motility index,gastric contraction frequency and intestinal peristalsis frequency were higher than that in control group(P＜0.05).Conclusion:Aspergillus oryzae pancreatin tablets by promoting the balance of intestinal flora,improving gastrointestinal function and regulating serum GLP-1 and PYY levels,which can alleviate the dyspepsia symptoms of patients with cirrhosis and improve the quality of life of patients.
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