摘要
目的:探讨米曲菌胰酶片对肝硬化相关消化不良患者肠道菌群、胃肠功能及血清胰高糖素样肽-1(GLP-1)和酪酪肽(PYY)水平的影响.方法:将我院129例肝硬化相关消化不良患者随机分为对照组(肝硬化常规治疗,n=64)和实验组(在对照组的基础上接受米曲菌胰酶片治疗,n=65).对比两组消化不良症状积分、肠道菌群指标、胃肠功能指标、血清GLP-1和PYY水平、生活质量变化情况.结果:实验组治疗第4周后消化不良症状积分、肠球菌、肠杆菌数量、GLP-1、PYY水平和NDI评分低于对照组,双歧杆菌、乳酸杆菌数量、胃排空率、胃运动指数、胃收缩频率、肠蠕动频率高于对照组(P＜0.05).结论:米曲菌胰酶片通过促进肠道菌群平衡、改善胃肠功能、调节血清GLP-1和PYY水平,可减轻肝硬化患者的消化不良症状,改善患者的生活质量.
Abstract
Objective:To investigate the effects of aspergillus oryzae pancreatin tablets on intestinal flora,gastrointestinal function and serum glucagon-like peptide-1(GLP-1)and casein peptide(PYY)levels in patients with cirrhosis-related dyspepsia.Methods:According to the random number table method,129 patients with liver cirrhosis-related dyspepsia who were treated in our hospital from March 2021 to December 2023 were divided into control group(routine treatment of liver cirrhosis,n=64)and experimental group(treated with aspergillus oryzae trypsin tablets on the basis of control group,n=65).The changes of dyspepsia symptom score,intestinal flora index,gastrointestinal function index,serum GLP-1 and PYY levels and quality of life were compared between two groups.Results:The scores of dyspepsia symptoms,the number of enterococcus,enterobacter,the levels of GLP-1,PYY and NDI score in experimental group were lower than that in control group 4 weeks after treatment,and the number of bifidobacteria,lactobacilli,the gastric emptying rate,gastric motility index,gastric contraction frequency and intestinal peristalsis frequency were higher than that in control group(P＜0.05).Conclusion:Aspergillus oryzae pancreatin tablets by promoting the balance of intestinal flora,improving gastrointestinal function and regulating serum GLP-1 and PYY levels,which can alleviate the dyspepsia symptoms of patients with cirrhosis and improve the quality of life of patients.
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