LncRNA SOCS2-AS1、miR-454-3p在人胃癌组织中的表达及临床意义
Expression and Clinical Significance of LncRNA SOCS2-AS1 and miR-454-3p in Human Gastric Cancer Tissues
许丽华 1张允 1仇俊兰 1张怀 1潘承祺1
作者信息
- 1. 南京大学医学院附属苏州医院肿瘤内科 江苏苏州 215000
- 折叠
摘要
目的:探讨长链非编码核糖核酸(LncRNA)细胞因子信号转导抑制因子2-反义转录本1(SOCS2-AS1)、微小核糖核酸(miR-NA)-454-3p在人胃癌组织中的表达及临床意义.方法:选取120例行胃癌根治术患者的胃癌组织和癌旁组织.检测上述组织中LncRNA SOCS2-AS1、miR-454-3p表达.分析LncRNA SOCS2-AS1、miR-454-3p表达与胃癌患者临床病理特征和预后的关系,多因素COX回归分析胃癌患者预后不良的影响因素.结果:胃癌组织中LncRNA SOCS2-AS1、miR-454-3p表达均低于癌旁组织(P＜0.05).LncRNA SOCS2-AS1、miR-454-3p表达与分化程度、浸润深度、淋巴结转移、TNM分期有关(P＜0.05).LncRNA SOCS2-AS1低表达组3年总生存率(OS)低于LncRNA SOCS2-AS1高表达组,miR-454-3p低表达组3年OS低于miR-454-3p高表达组(P＜0.05).发生淋巴结转移、TNM分期Ⅲ期是胃癌患者预后不良的危险因素(P＜0.05),miR-454-3p、LncRNA SOCS2-AS1高表达是胃癌患者预后不良的保护因素(P＜0.05).结论:胃癌组织中LncRNA SOCS2-AS1、miR-454-3p呈低表达,二者与胃癌患者病理特征及预后不良密切相关.
Abstract
Objective:To investigate the expression and clinical significance of long non-coding ribonucleic acids(LncRNA)cy-tokine signal transduction inhibitor 2-antisense transcript 1(SOCS2-AS1)and micribonucleic acid(miRNA)-454-3p in human gastric cancer tissues.Methods:The gastric cancer tissues and adjacent tissues of 120 patients undergoing radical gastrectomy were selected.The expression of LncRNA SOCS2-AS1 and miR-454-3p in above-mentioned tissues were detected.After 3 years of follow-up,the rela-tionship between the expression of LncRNA SOCS2-AS1,miR-454-3p and the clinical pathological characteristics and prognosis of gas-tric cancer patients by analysis,and the influencing factors of poor prognosis in gastric cancer patients were analyzed by multivariate COX regression.Results:The expression of LncRNA SOCS2-AS1 and miR-454-3p in gastric cancer tissues was lower than that in adja-cent tissues(P＜0.05).The expression of LncRNA SOCS2-AS1 and miR-454-3p was related to the degree of differentiation,depth of in-vasion,lymph node metastasis and TNM stage(P＜0.05).The 3-year overall survival(OS)in LncRNA SOCS2-AS1 low expression group was lower than that in LncRNA SOCS2-AS1 high expression group,and the 3-year OS in miR-454-3p low expression group was lower than that in miR-454-3p high expression group(P＜0.05).Lymph node metastasis and TNM stage Ⅲ were risk factors for poor prognosis in gastric cancer patients(P＜0.05).High expression of miR-454-3p and LncRNA SOCS2-AS1 was a protective factor for poor prognosis in gastric cancer patients(P＜0.05).Conclusion:The low expression of LncRNA SOCS2-AS1 and miR-454-3p in gastric cancer tissues is closely related to the pathological characteristics and poor prognosis of gastric cancer patients.
关键词
胃癌/LncRNA/SOCS2-AS1/miR-454-3p/病理特征/预后Key words
Gastric cancer/LncRNA SOCS2-AS1/miR-454-3p/Pathological features/Prognosis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据