Expression and Clinical Significance of LncRNA SOCS2-AS1 and miR-454-3p in Human Gastric Cancer Tissues
Objective:To investigate the expression and clinical significance of long non-coding ribonucleic acids(LncRNA)cy-tokine signal transduction inhibitor 2-antisense transcript 1(SOCS2-AS1)and micribonucleic acid(miRNA)-454-3p in human gastric cancer tissues.Methods:The gastric cancer tissues and adjacent tissues of 120 patients undergoing radical gastrectomy were selected.The expression of LncRNA SOCS2-AS1 and miR-454-3p in above-mentioned tissues were detected.After 3 years of follow-up,the rela-tionship between the expression of LncRNA SOCS2-AS1,miR-454-3p and the clinical pathological characteristics and prognosis of gas-tric cancer patients by analysis,and the influencing factors of poor prognosis in gastric cancer patients were analyzed by multivariate COX regression.Results:The expression of LncRNA SOCS2-AS1 and miR-454-3p in gastric cancer tissues was lower than that in adja-cent tissues(P＜0.05).The expression of LncRNA SOCS2-AS1 and miR-454-3p was related to the degree of differentiation,depth of in-vasion,lymph node metastasis and TNM stage(P＜0.05).The 3-year overall survival(OS)in LncRNA SOCS2-AS1 low expression group was lower than that in LncRNA SOCS2-AS1 high expression group,and the 3-year OS in miR-454-3p low expression group was lower than that in miR-454-3p high expression group(P＜0.05).Lymph node metastasis and TNM stage Ⅲ were risk factors for poor prognosis in gastric cancer patients(P＜0.05).High expression of miR-454-3p and LncRNA SOCS2-AS1 was a protective factor for poor prognosis in gastric cancer patients(P＜0.05).Conclusion:The low expression of LncRNA SOCS2-AS1 and miR-454-3p in gastric cancer tissues is closely related to the pathological characteristics and poor prognosis of gastric cancer patients.
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