Expression of MAGEA4 and NY-ESO-1 in Non-Small Cell Lung Cancer and Their Relationship with Clinicopathological Features and Prognosis
Objective:To investigate the relationship between the expression of melanoma-associated antigen A4(MAGEA4)and New York esophageal squamous cell carcinoma antigen 1(NY-ESO-1)in non-small cell lung cancer(NSCLC)tissues and clinicopatho-logical features and prognosis.Methods:309 NSCLC patients in our hopital were selected,surgically resected cancer tissues and adjacent tissues were taken,the expression of MAGE A4 and NY-ESO-1 was detected.The expression differences of MAGEA4 and NY-ESO-1 in NSCLC tissues with different clinicopathological features were compared.Followed up for 3 years,the relationship between MAGEA4 and NY-ESO-1 expression and prognosis of NSCLC patients and the factors affecting prognosis of NSCLC patients were analyzed.Results:The positive expression rates of MAGEA4 and NY-ESO-1 in NSCLC cancer tissues were higher than in adjacent tissues(P＜0.05).The increased positive expression rates of MAGEA4 and NY-ESO-1 in NSCLC patients were associated with low differentiation,TNM stage Ⅲ A,and lymph node metastasis(P＜0.05).The 3-year overall survival(OS)rate of MAGEA4,NY-ESO-1 positive expression was lower than that of MAGEA4,NY-ESO-1 negative expression(P＜0.05).MAGEA4 positive expression,lymph node metastasis,TNM stage ⅢA and NY-ESO-1 positive expression were risk factors for poor prognosis of NSCLC patients(P＜0.05).Conclusion:The positive expression rates of MAGEA4 and NY-ESO-1 in NSCLC tissues are increase,which are relate to lymph node metastasis,TNM stage ⅢA,poor differentiationand poor prognosis of NSCLC patients.
NETL
NSTL
万方数据
