非小细胞肺癌组织MAGEA4、NY-ESO-1表达及其与临床病理特征和预后的关系
Expression of MAGEA4 and NY-ESO-1 in Non-Small Cell Lung Cancer and Their Relationship with Clinicopathological Features and Prognosis
刘平闯 1张文辉 2王迪 3孙宜田 2张灿堂 2陈玉玲2
作者信息
- 1. 徐州医科大学研究生学院 江苏徐州 221000;徐州医科大学附属医院呼吸与危重症医学科 江苏徐州 221000
- 2. 徐州医科大学附属医院呼吸与危重症医学科 江苏徐州 221000
- 3. 徐州医科大学研究生学院 江苏徐州 221000
- 折叠
摘要
目的:探讨非小细胞肺癌(NSCLC)组织黑素瘤相关抗原A4(MAGEA4)、纽约食管鳞状上皮癌抗原1(NY-ESO-1)表达与临床病理特征和预后的关系.方法:选取我院309例NSCLC患者,取手术切除的癌组织和癌旁组织检测MAGEA4和NY-ESO-1表达.比较不同临床病理特征NSCLC组织中MAGEA4、NY-ESO-1表达差异.随访3年,分析MAGEA4、NY-ESO-1表达与NSCLC患者预后的关系以及影响NSCLC患者预后的因素.结果:NSCLC癌组织MAGEA4、NY-ESO-1的阳性表达率高于癌旁组织(P＜0.05).NSCLC患者中MAGEA4、NY-ESO-1阳性表达率增高与低分化、TNM分期ⅢA期、淋巴结转移有关(P＜0.05).MAGEA4、NY-ESO-1阳性表达3年总生存(OS)率低于MAGEA4、NY-ESO-1阴性表达患者(P＜0.05).MAGEA4阳性表达、淋巴结转移、TNM分期ⅢA期、NY-ESO-1阳性表达是NSCLC患者不良预后的危险因素(P＜0.05).结论:NSCLC组织中MAGEA4和NY-ESO-1阳性表达率升高,与淋巴结转移、TNM分期ⅢA期、低分化和NSCLC患者不良预后有关.
Abstract
Objective:To investigate the relationship between the expression of melanoma-associated antigen A4(MAGEA4)and New York esophageal squamous cell carcinoma antigen 1(NY-ESO-1)in non-small cell lung cancer(NSCLC)tissues and clinicopatho-logical features and prognosis.Methods:309 NSCLC patients in our hopital were selected,surgically resected cancer tissues and adjacent tissues were taken,the expression of MAGE A4 and NY-ESO-1 was detected.The expression differences of MAGEA4 and NY-ESO-1 in NSCLC tissues with different clinicopathological features were compared.Followed up for 3 years,the relationship between MAGEA4 and NY-ESO-1 expression and prognosis of NSCLC patients and the factors affecting prognosis of NSCLC patients were analyzed.Results:The positive expression rates of MAGEA4 and NY-ESO-1 in NSCLC cancer tissues were higher than in adjacent tissues(P＜0.05).The increased positive expression rates of MAGEA4 and NY-ESO-1 in NSCLC patients were associated with low differentiation,TNM stage Ⅲ A,and lymph node metastasis(P＜0.05).The 3-year overall survival(OS)rate of MAGEA4,NY-ESO-1 positive expression was lower than that of MAGEA4,NY-ESO-1 negative expression(P＜0.05).MAGEA4 positive expression,lymph node metastasis,TNM stage ⅢA and NY-ESO-1 positive expression were risk factors for poor prognosis of NSCLC patients(P＜0.05).Conclusion:The positive expression rates of MAGEA4 and NY-ESO-1 in NSCLC tissues are increase,which are relate to lymph node metastasis,TNM stage ⅢA,poor differentiationand poor prognosis of NSCLC patients.
关键词
非小细胞肺癌/黑素瘤相关抗原A4/纽约食管鳞状上皮癌抗原1/病理特征/预后Key words
Non-small cell lung cancer/Melanoma-associated antigen A4/New York esophageal squamous cell carcinoma antigen 1/Pathological features/Prognosis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据