Analysis of the Relationship between the Expression of TRPM7 and TRPM8 in Bladder Urothelial Carcinoma Tissue and Clinicopathological Features and Prognosis
Objective:To investigate the relationship between the expression of transient receptor potential cation channel subfamily M member 7(TRPM7)and transient receptor potential cation channel subfamily M member 8(TRPM8)in bladder urothelial carcinoma(BUC)and clinicopathological features and prognosis.Methods:127 BUC patients were selected and collect cancer tissues and adjacent tissues during the operation.The expression of TRPM7 and TRPM8 in cancer tissues and adjacent tissues were compared,and the rela-tionship between the expression of TRPM7 and TRPM8 in cancer tissues and clinicopathological features was analyzed.Followed up for 3 years,the prognosis of patients and the influencing factors of death with difference TRPM7 and TRPM8 expression were analyzed.Results:The positive expression rates of TRPM7 and TRPM8 in cancer tissues were significantly higher than those in adjacent tissues(P＜0.05).The proportion of pathological stage T2～T4,and lymph node metastasis in patients with positive expression of TRPM7 and TRPM8 was significantly higher than that in patients with negative expression of TRPM7 and TRPM8(P＜0.05).The 3-year survival rate of patients with positive expression of TRPM7 and TRPM8 was significantly lower than that of patients with negative expression of TRPM7 and TRPM8(P＜0.05).lymph node metastasis,TRPM7 positive expression and TRPM8 positive expression were independent risk factors for poor prognosis in BUC patients(P＜0.05).Conclusion:The positive expression of TRPM7 and TRPM8 in BUC tissues are closely relate to pathological stage,and lymph node metastasis,and the positive expression of TRPM7 and TRPM8 are independent risk factors for poor prognosis in BUC patients.
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