Predictive Value of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Combined with Serum SCCA,TSGF and HE4 in Lymph Node Metastasis of Early Cervical Cancer
Objective:To investigate the predictive value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)combined with serum squamous cell carcinoma antigen(SCCA),tumor specific growth factor(TSGF)and epididymis protein 4(HE4)in lymph node metastasis(LNM)of early cervical cancer.Methods:112 patients with early cervical cancer were divided into LNM group(27 cases)and non LNM group(85 cases)according to the results of postoperative pathological examination.The general data,DCE-MRI quantitative parameters[rate constant(Kep),volume transfer constant(Ktrans),extravascular extracellular volume fraction(Ve)],serum SCCA,TSGF and HE4 levels were compared between two groups.The predictive value of DCE-MRI quantitative parameters com-bined with serum SCCA,TSGF and HE4 for LNM in patients with early cervical cancer were analyzed by receiver operating characteristic(ROC)curve.Results:The proportion of international federation of gynecology and obstetrics(FIGO)stage ⅡA1～ⅡA2,levels of serum SCCA,TSGF,HE4,Kep and Ktrans in LNM group were higher than that in non LNM group(P＜0.05).There was no significant difference in Ve between two groups(P＞0.05).Kep,Ktrans,serum SCCA,TSGF,HE4 alone and in combination had high sensitivity and specificity in pre-dicting LNM in patients with early cervical cancer,the area under the curve(AUC)of combined test in predicting LNM in patients with early cervical cancer was higher than that of each index alone.Conclusion:DCE-MRI quantitative parameters combined with serum SCCA,TSGF and HE4 have high predictive value for LNM in patients with early cervical cancer,and can be used for auxiliary predic-tion of LNM in early cervical cancer.
Dynamic contrast-enhanced magnetic resonance imagingSCCATSGFHE4Cervical cancerLymph node metastasisPredictive value
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