The Expression Significance of Statin B and Bone Morphogenetic Protein 15 in Serum of Premature Ovarian Insufficiency and Their Relationship with Pregnancy Loss after Treatment
Objective:To analyze the significance of the expression of inhibin B and bone morphogenetic protein 15 in serum of premature ovarian insufficiency and their relationship with pregnancy failure after treatment.Methods:102 patients with early-onset ovar-ian insufficiency admitted from 2021.6-2023.6 were selected for the observation group and were divided into menopausal and non-menopausal groups.In addition,102 women with healthy physical examination and normal menstruation in the same period were in-cluded in the control group to analyze relevant indicators.Results:The expression levels of serum inhibin B and bone morphogenic pro-tein 15 were all lower in the observation group(P＜0.05);The expression levels of serum inhibin B and bone morphogenic protein 15 in the menopausal group were all lower than those in the non-menopausal group(P＜0.05);The expression levels of serum inhibin B and bone morphogenic protein 15 in patients with early-onset ovarian insufficiency were both negatively correlated with luteinizing hormone and FSH,A positive correlation with oestradiol(P＜0.05);A higher pregnancy failure rate after treatment in the low inhibin B group than in the high inhibin B group,The posttreatment pregnancy failure rate was higher in low bone morphogen protein group 15 than in high bone morphogen protein group 15(P＜0.05);Serum inhibin B combined with bone morphogenetic protein 15 showed a sensitivity of 92.52％,a specificity of 63.47％,and an AUC of 0.915.Conclusion:Serum inhibin B and bone morphogenic protein 15 were both down-regulated in patients with early-onset ovarian insufficiency,which is closely related to the degree of ovarian dysfunction,and was better combined to predict pregnancy failure after treatment.
Premature ovarian insufficiencyStatin BBone morphogenetic protein 15Ovarian functionPregnancy failure
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