Growth Hormone Deficiency Role of Recombinant Human Growth Hormone Treatment before and after the Change of the Vitamin D Levels and Its Prognostic Factors Analysis
Objective:To analyze the changes of vitamin D levels and prognostic factors in children with growth hormone defi-ciency before and after treatment with recombinant human growth hormone.Methods:80 children with GH deficiency admitted during 2020.2-2023.2 were selected for recombinant human GH therapy.Compare relevant indicators and analyze prognostic factors.Results:The height,height standard deviation score and growth rate of children with GH deficiency increased compared with those before treat-ment(P＜0.05);The serum expression levels of IGF-1 and IGFBP-3 in children with GH deficiency increased compared with those before treatment(P＜0.05);Serum 25(OH)D3,1,The expression level of 25-(OH)2D3 was increased compared with that before treatment(P＜0.05);After the univariate and multivariate Logistic regression analysis,Pre-treatment growth rate,bone age maturity,and maternal preg-nancy comorbidities were all independent factors for outcomes in children with GH deficiency(P＜0.05).Conclusion:The growth-pro-moting effect of recombinant human growth hormone treatment helps to promote the metabolism of vitamin D,but the prognosis is influ-enced by pre-treatment growth rate,pre-treatment bone age maturity and maternal pregnancy comorbidities.
Growth hormone deficiencyRecombinant human growth hormoneVitamin D
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