Plasma t-pregnant Women of Placental Abruption PAIC,TAT Level Changes in the Meaning and the Disease Severity,the Relationship between Diffuse Intravascular Coagulation
Objective:To analyze the significance of plasma tissue plasminogen activator inhibitor complex(t-PAIC)and thrombi-nase-antithrombin complex(TAT)levels in pregnant women with placental abruption and their relationship with disease severity and dis-seminated intravascular coagulation.Methods:105 pregnant women with placental abruption who underwent regular examination from 2018.6-2023.6 were selected for observation and divided into light and heavy groups according to severity;105 normal pregnant women in the same period were included in the control group.Test the indicators and analyze the correlation and diagnostic value.Results:The plasma levels of t-PAIC and TAT in the observation group were higher than that in the control group(P＜0.05);Plasma t-PAIC and TAT levels in the heavy group were higher than those in the light group(P＜0.05);The plasma t-PAIC and TAT levels in pregnant women with placental abruption were positively correlated with their delivery bleeding volume(P＜0.05);Plasma t-PAIC and TAT predicted the sensi-tivity of heavy placental abruption as 89.43％,61.23％specific,and AUC as 0.901;Plasma t-PAIC combined with TAT predicted the sensitivity of 92.56％,60.47％specificity and 0.920 AUC in pregnant women with placental abruption.Conclusion:The plasma levels of t-PAIC and TAT are increased in pregnant women with placental abruption,which are related to the severity of their disease,and the combination can further improve the predictive efficacy of secondary disseminated intravascular coagulation.
placental abruptiont-PAICTATDegree of severityDiffuse intravascular coagulation
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