Analysis of the Effect of Venetoclax Combined with Azacytidine on T Lymphocyte Subsets in Elderly Patients with Acute Myeloid Leukemia and the Influencing Factors of its Efficacy
Objective:To observe the effect of venetoclax combined with azacytidine on T lymphocyte subsets in elderly patients with acute myeloid leukemia(AML),and to analyze the influencing factors of efficacy.Methods:238 elderly AML patients were divided into control group(n=120,treated with azacitidine)and study group(n=1 18,treated with venetoclax combine with azacitidine)according to the different treatment options.The efficacy,changes of T lymphocyte subsets and incidence of adverse reactions were compared in two groups.The influencing factors that affect the poor efficacy were analyzed by multivariate logistic regression.Results:Compared with control group,the total clinical effective rate in study group after treatment was higher,CD3+,CD4+,CD4+/CD8+were higher,and CD8+was lower(P＜0.05).There was no difference in the total incidence of adverse reactions between two groups(P＞0.05).Low platelet count(PLT),high lactate dehydrogenase(LDH),and high Chalson comorbidities index(CCI)score were risk factors for poor efficacy(P＜0.05).Conclusion:Vinecra combined with azacytidine can effectively improve the clinical efficacy and immune function of elderly AML patients.In addition,the efficacy of elderly AML patients is also affected by PLT,LDH,and CCI scores.
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