摘要
目的:探讨血清asprosin、microRN A-20a-5p、miR-13 7在糖尿病性视网膜病变的水平变化及临床意义方法:选取2022.4-2024.4于医院收治的2型糖尿病患者(T2DM组)120例,并根据是否发生DR分为DR组60例,非DR组60例,在DR组内按照疾病的严重程度分为PDR40例以及NPDR20例,选取40例健康体检者为对照组,对比分析相关指标.结果:与对照组相比 asprosin、miR-137 在 T2DM 患者中均升高,miRNA-20a-5p 降低(P＜0.05).DR 组患者年龄、HbA1、FPG、LDL-C、asprosin、miR-137高于NDR组,病程长于NDR组,miR-20a-5p低于NDR组(P＜0.05).PDR组中病程、空腹血糖、糖化血红蛋白、asprosin和miR-137高于NPDR组,miR-20a-5p低于NPDR组(P＜0.05).病程、空腹血糖、糖化血红蛋白、asprosin和miR-137属于DR发生的独立危险因素,而miR-20a-5p为独立保护因素.结论:血清中asprosin、microRNA-20a-5p、miR-137的水平变化T2DM并发DR密切相关,可能成为DR防治的监测指标及靶点.
Abstract
Objective:To explore the changes and clinical significance of serum asprosin,microRNA-20a-5p,and miR-137 levels in diabetic retinopathy.Methods:120 patients(T2DM group)with type 2 DM were selected for 2022.4-20240 patients in DR group,60 patients in non-DR group,and 40 PDR and NPDR20 cases in DR group,40 healthy examination patients were selected as the control group,and relevant indicators were analyzed.Results:Compared with controls,asprosin and miR-137 were increased in T2DM patients,and miRNA-20a-5p was decreased(P＜0.05).In the DR group,their age,HbA 1,FPG,LDL-C,asprosin,and miR-137 were higher than the NDR group,their disease duration was longer than the NDR group,and their miR-20a-5p was lower than the NDR group(P＜0.05).In the PDR group,disease course,fasting glucose,hemoglobin A 1 c,asprosin and miR-137 were higher than that in the NPDR group,miR-20a-5p was lower than that in the NPDR group(P＜0.05).Disease duration,fasting glucose,HbA 1 c,asprosin and miR-137 were independent risk factors for the development of DR,while miR-20a-5p was an independent protective factor.Conclusion:The levels of asprosin,microRNA-20a-5p and miR-137 in serum are closely related between T2DM and DR,which may become the monitoring index and target of DR prevention and treatment.
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