Level Changes and Clinical Significance of Serum Asprosin,microRNA-20a-5p,and miR-137 in Diabetic Retinopathy
Objective:To explore the changes and clinical significance of serum asprosin,microRNA-20a-5p,and miR-137 levels in diabetic retinopathy.Methods:120 patients(T2DM group)with type 2 DM were selected for 2022.4-20240 patients in DR group,60 patients in non-DR group,and 40 PDR and NPDR20 cases in DR group,40 healthy examination patients were selected as the control group,and relevant indicators were analyzed.Results:Compared with controls,asprosin and miR-137 were increased in T2DM patients,and miRNA-20a-5p was decreased(P＜0.05).In the DR group,their age,HbA 1,FPG,LDL-C,asprosin,and miR-137 were higher than the NDR group,their disease duration was longer than the NDR group,and their miR-20a-5p was lower than the NDR group(P＜0.05).In the PDR group,disease course,fasting glucose,hemoglobin A 1 c,asprosin and miR-137 were higher than that in the NPDR group,miR-20a-5p was lower than that in the NPDR group(P＜0.05).Disease duration,fasting glucose,HbA 1 c,asprosin and miR-137 were independent risk factors for the development of DR,while miR-20a-5p was an independent protective factor.Conclusion:The levels of asprosin,microRNA-20a-5p and miR-137 in serum are closely related between T2DM and DR,which may become the monitoring index and target of DR prevention and treatment.
Type 2 diabetesDiabetic retinopathyAsprosinmiR-20a-5pmiR-137
NETL
NSTL
万方数据
