Study on Relationship between Serum CXCL12/CXCR4/CXCR7 Signal Axis Level and Disease Activity and Prognosis in Patients with Lupus Nephritis
Objective:To investigate the relationship between the expression levels of serum chemokine C-X-C motif ligand 12(CXCL12),chemokine C-X-C motif receptor 4(CXCR4),chemokine C-X-C motif receptor 7(CXCR7),disease activity and prognosis in patients with lupus nephritis(LN).Methods:274 patients with LN were selected as LN group.Patients were divided into LN active group(n=146)and LN stable group(n=128)according to the disease activity of LN patients,and 274 healthy volunteers were selected as the healthy control group.The correlation of main clinical indicators were analyzed by Pearson method.2 years after follow-up,patients with LN were categorized into a good prognosis group(n=198)and a poor prognosis group(n=70)based on their prognosis.The influ-encing factors were analyzed by multivariate Logistic regression analysis.Results:The expression levels of serum CXCL12,CXCR4 and CXCR7 in LN group were higher than those in healthy control group(P＜0.05).The levels of urinary protein,C-reactive protein(CRP),CXCL12,CXCR4 and CXCR7 in LN active group were higher than those in LN stable group,and the levels of complement C3 and com-plement C4 were lower than those in LN stable group(P＜0.05).The expression levels of serum CXCL12,CXCR4 and CXCR7 in LN patients were positively correlated with urinary protein and CRP,and negatively correlated with complement C3 and complement C4(P＜0.05).Elevated levels of urinary protein,CXCL12,CXCR4 and CXCR7 were independent risk factors for poor prognosis in LN patients(P＜0.05).Conclusion:The expression levels of serum CXCL12,CXCR4 and CXCR7 in LN patients are increased,which are closely related to the disease activity and poor prognosis of LN patients.
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