The Value of uKIM-1,uβ2-MG and Serum UA in the Diagnosis of Renal Dysfunction
Objective:To determine the diagnostic value of serum uric acid(UA),urine β2-microglobulin(uβ2-MG)and urine kidney injury molecule-1(uKIM-1)in patients with renal dysfunction.Methods:The study was cross-sectional designed.Clinical,laboratory and histologic data of renal insufficient patients from the department of Nephrology,Zhongshan Hospital,China,from March 1,2022,to August 31,2022 were collected.Demographic,laboratory,and pathological information were extracted,and uKIM-1,uβ2-MG levels were detected by enzyme-linked immunosorbent assay.Serum UA,urine Cr and serum Cr were extracted by electronic medical record system.According to the 24-hour urine protein(24h-UP)and estimated glomerular filtration rate(eGFR),the enrolled patients were divided into three categories:proteinuria,eGFR-decreasing,and extremely high-risk of chronic kidney disease(CKD).Compare the demographic and clinical characteristics of kidney insufficient patients among different groups,use logistic regression model to analyze the correlation between serum UA/Cr,uβ2-MG,uKIM-1 and kidney injury related indicators,and evaluate the clinical diagnostic value of serum UA/Cr,uβ2-MG,and uKIM-1 for patients of renal dysfunction based on the ROC curve.Results:The logistic regression model adjusted for age and gender showed that UA/Cr and uβ2-MG were significantly correlated with extremely high-risk of CKD,while uKIM-1/Cr was not statistically correlated with all renal dysfunction outcomes.ROC curve analysis showed that the area under the curve(AUC)of UA/Cr,uβ2-MG and uKIM-1/Cr in evaluating eGFR-reduced renal dysfunction were 0.887,0.970,and 0.720 respectively.The AUC of extremely high-risk of CKD were 0.868,0.821 and 0.684 respectively.Conclusion:Serum UA/Cr have high diagnostic value for extremely high-risk of CKD,and uβ2-MG have high diagnostic value for eGFR-decreasing renal dysfunction.It is recommended to carry out relevant index follow-up in early clinical stage to effectively prevent the progression of kidney injury.
万方数据
维普
