Diagnostic Value of Neutrophil/lymphocyte Ratio and Platelet/lymphocyte Ratio in Patients with Asthma
Objective:To explore the distribution of neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)in patients with asthma and their diagnostic value.Methods:Patients from Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine were selected from January 2020 to January 2021.87 patients with asthma were collected as asthma group,and 90 healthy subjects as control group.The clinical laboratory examination indicators were analyzed,and the correlations between NLR,PLR and WBC,LY,EO and other inflammatory indicators were analyzed by Pearson correlation.Receiver operating characteristic(ROC)curves were used to evaluate the diagnostic efficacy of NLR and PLR alone or in combination for asthma.Results:Compared with the control group,the levels of NLR(P＜0.001)and PLR(P＜0.001)in the asthma group were signifiicantly increased.Pearson correlation analysis found that in asthmatic patients,NLR and PLR were negatively correlated with LY(P＜0.05),and positively correlated with NE,WBC and RDW(P＜0.05).The AUC of NLR for diagnosing asthma was 0.830(95％CI 0.763-0.897),when the optimal cut-off value was 2.320,the sensitivity was 74.7％,and the specificity was 87.8％;the AUC of PLR for diagnosing asthma was 0.582(95％CI 0.495-0.669),when the optimal cut-off value is 171.615,the sensitivity is 34.5％,and the specificity is 91.1％.Among the individual indicators,NLR had the highest ROC for the diagnosis of asthma,that is,the highest diagnostic efficiency.The AUC of NLR+PLR+WBC+MPV+NE+MO+MCV+RDW combined diagnosis of asthma was higher than other indicators.Conclusion:The levels of NLR and PLR in peripheral blood of patients with asthma are increased.The effectiveness of NLR in diagnosing asthma was better than that of PLR,WBC,MPV,NE,MO,MCV,and RDW,and the combined efficacy of NLR+PLR+WBC+MPV+NE+MO+MCV+RDW is the highest.
万方数据
维普
