Expression of Serum CCL17,GDF-15 and ANG2 Levels in Children with Severe Pneumonia and Their Prognostic Value
Objective:To investigate the expression of serum chemokine ligand 17(CCL17),growth differentiation factor-15(GDF-15)and angiopoietin 2(ANG2)in children with severe pneumonia(SP)and their prognostic value.Methods:344 SP children(SP group)and 150 healthy children(control group)were selected.The levels of serum CCL17,GDF-15,ANG2,inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT)]were detected and compared between two groups.Multivariate logistic regression was used to analyze the prognostic factors of children with SP.The prognostic value of serum GDF-15,ANG2 and CCL17 in children with SP was analyzed using receiver operating characteristic(ROC)curves.Results:Compared with control group,the levels of serum CCL17,GDF-15,ANG2,IL-6,CRP and PCT in SP group were significantly increased(P＜0.05).The decrease of pediatric critical illness score(PCIS)and the increase of serum CCL17,GDF-15 and ANG2 levels were risk factors for poor prognosis in children with SP(P＜0.05).The results of ROC curve analysis showed that,the areas under the curve(AUC)of CCL17,GDF-15 and ANG2 alone and in combination for predicting the prognosis of children with SP were 0.833,0.801,0.806 and 0.974,respectively,the value of combined prediction of poor prognosis in children with SP was higher than that of each index alone(P＜0.05).Conclusion:The levels of serum CCL17,GDF-15 and ANG2 in children with SP are abnormally high,and are closely related to the poor prognosis,the combined detection of the three indexes has a high value in predicting the poor prognosis of children with SP.
Severe pneumoniaChemokine ligand 17Growth differentiation factor-15Angiopoietin-2Inflammatory factorPrognosis
万方数据
维普
