Study on the Relationship between Epithelial Membrane Protein 1 and ETS Variant Transcription Factor 4 in Colorectal Cancer Tissues and Clinicopathological Features and Prognosis
Objective:To investigate the relationship between epithelial membrane protein 1(EMP1),ETS variant transcription factor 4(ETV4)and clinicopathological features and prognosis in colorectal cancer(CRC)tissues.Methods:CRC tissues and adjacent tissues of 180 CRC patients were collected,the positive expression rates of EMP1 and ETV4 in different tissues were compared,and the relationship between the two and clinicopathological features of CRC patients were analyzed.CRC patients were divided into EMP1 and ETV4 positive/negative groups based on their EMP1 and ETV4 positive expression,3 years after follow-up,the 3-year overall survival rate were analyzed by Kaplan-Meier survival curve.The influencing factors were analyzed by Multivariate Cox regression analysis.Results:The positive expression rate of EMP1 in CRC tissues was 36.11％,which was lower than that in adjacent tissues.The positive expression rate of ETV4 was 61.11％,which was higher than that in adjacent tissues(P＜0.05).The expression of EMP1 and ETV4 were related to the lymph node metastasis,degree of differentiation and TNM stage(P＜0.05).During a 3 years after follow-up,3 cases were lost to follow-up,the 3-year overall survival rate of CRC patients was 71.75％(127/177).The 3-year overall survival rate of EMP1 posi-tive group was higher than that of EMP1 negative group(P＜0.05).The 3-year overall survival rate of ETV4 positive group was lower than that of ETV4 negative group(P＜0.05).Lymph node metastasis,TNM stage Ⅲ,EMP1 negative,poor differentiation and ETV4 posi-tive were risk factors for poor prognosis in CRC patients(P＜0.05).Conclusion:The rate of EMP1 positive expression decreased and ETV4 positive expression increased in CRC tissues,which are closely related to the differentiation degree of differentiation,TNM stage,lymph node metastasis and poor prognosis in CRC patients.
Colorectal cancerEpithelial membrane protein 1ETS variant transcription factor 4Clinicopathological featuresProg-nosis
万方数据
维普
