Correlation between the Expression of TL1A,sPD-1mRNA in Peripheral Blood Mononuclear Cells and the Imbalance of Th17/Treg in Patients with Oral Lichen Planus
Objective:To investigate the correlation between the expression of tumor necrosis factor-like ligand 1A(TL1A)and soluble programmed death receptor 1(sPD-1)messenger ribonucleic acid(mRNA)in peripheral blood mononuclear cells and the imbalance of helper T cell 17(Th17)/regulatory T cell(Treg)in patients with oral lichen planus(OLP).Methods:133 patients with OLP(OLP group)were divided into erosive group(74 cases)and non-erosive group(59 cases)according to the type of damage.The expression of TL1A mRNA and sPD-1 mRNA in peripheral blood mononuclear cells,the expression of retinoic acid-related orphan nuclear receptor γt(RORγt)mRNA and forkhead box protein P3(FOXP3)mRNA in peripheral blood,and the proportion of Th 17 and Treg cells were detected.The relationship between the expression of TL1A mRNA,sPD-1 mRNA and Th17/Treg related factors were analyzed by Pearson/Spearman correlation analysis.Results:Compared with non-erosive group,the expression levels of TL1A mRNA,sPD-1 mRNA and RORγt mRNA in peripheral blood mononuclear cells,the proportion of Th 17 and the ratio of Th17/Treg in peripheral blood were increased,the proportion of Treg and the expression of FOXP3 mRNA in peripheral blood were decreased in erosive group(P＜0.05).Correlation analysis showed that,the expression of TL1A mRNA and sPD-1 mRNA in peripheral blood mononuclear cells of OLP patients were positively correlated with the proportion of Th17,the expression of RORγt mRNA and the ratio of Th17/Treg in peripheral blood,and negatively correlated with the proportion of Treg and the expression of FOXP3 mRNA in peripheral blood(P＜0.05).Conclusion:The abnormal high expression of TL1A and sPD-1 in peripheral blood mononuclear cells of OLP patients,which are closely related to Th17/Treg imbalance,TL1A and sPD-1 may participate in the occurrence and development of OLP by causing Th17/Treg imbalance.
Oral lichen planusTumor necrosis factor-like ligand 1ASoluble programmed death receptor 1Imbalance of helper T cell 17/regulatory T cell imbalance
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维普
