Objective:To analyze the relationship between serum CC chemokine receptor 3(CCR3),CC chemokine ligand 7(CCL7)and postoperative recurrence and metastasis in patients undergoing radical resection of colorectal cancer.Methods:310 patients who underwent radical resection of colorectal cancer were selected as the study group,and 180 healthy volunteers as the control group.serum levels of CCR3 and CCL7 in two groups were detected.The relationship between serum CCR3 and CCL7 and clinical pathological features was ananlyzed.Followed up for 3 years and divided into non-recurrence and metastasis group and recurrence and metastasis group based on prognosis.The influencing factors of postoperative recurrence and metastasis were analyzed.Results:Compared with the control group,the study group had higher levels of serum CCR3 and CCL7(P＜0.05).The serum levels of CCR3 and CCL7 in patients with lymph node metastasis and TNM stage Ⅲ were significantly higher than those in patients without lymph node metastasis and TNM stage Ⅰ～Ⅱ(P＜0.05).The serum levels of CCR3 and CCL7 in recurrence and metastasis group were signifiicantly higher than those in non-recurrence and metastasis group(P＜0.05).The risk factors for postoperative recurrence and metastasis in colorectal cancer patients included lymph node metastasis,elevated CCR3,and elevated CCL7(P＜0.05).Conclusion:Elevated serum levels of CCR3 and CCL7 in colorectal cancer patients are risk factors for postoperative recurrence and metastasis.
关键词
结直肠癌/CC趋化因子受体3/CC趋化因子配体7/复发转移
Key words
Colorectal cancer/CC chemokine receptor 3/CC chemokine ligand 7/Recurrence and metastasis
维普
万方数据