Study on the Relationship between Serum IMA,Gal-3 and Sudden Cardiac Death after PCI in Patients with Acute ST-Segment Elevation Myocardial Infarction Complicated with HFpEF
Objective:To investigate the relationship between serum ischemia modified albumin(IMA),galectin-3(Gal-3)and sudden cardiac death after percutaneous coronary intervention(PCI)in patients with acute ST-segment elevation myocardial infarction(STEMI)complicated with heart failure with preserved ejection fraction(HFpEF).Methods:205 patients with acute STEMI complicated with HFpEF who underwent PCI were followed up for 1 year,45 patients with sudden cardiac death were included in the study group,and 160 patients without sudden cardiac death were included in the control group during the follow-up period.The levels of serum IMA and Gal-3 before PCI were compared between two groups.The influencing factors of sudden cardiac death after PCI were analyzed by multivariate Logistic regression analysis.Results:Compared with control group,the levels of serum IMA and Gal-3 in study group before PCI were higher(all P＜0.05).Multivariate Logistic regression analysis showed that,elevated preoperative serum IMA level,elevated Gal-3 level,multi-vessel disease,and cardiac function Killip grade IV were independent risk factors for sudden cardiac death in patients with acute STEMI complicated with HFpEF after PCI(P＜0.05).Conclusion:Elevated serum IMA and Gal-3 levels are risk factors for sudden cardiac death in patients with acute STEMI complicated with HFpEF after PCI.
Acute ST-segment elevation myocardial infarctionHeart failure with preserved ejection fractionIschemia modified albuminGalectin-3Percutaneous coronary interventionSudden cardiac death
万方数据
维普
