Effects of Different Doses of Tibolone Combined with Calcium Amino Acid Chelate on Bone Fracture Prevention,Serum Bone Metabolism Indexes and Adipokines in Postmenopausal Osteoporosis
Effects of Different Doses of Tibolone Combined with Calcium Amino Acid Chelate on Bone Fracture Prevention,Serum Bone Metabolism Indexes and Adipokines in Postmenopausal Osteoporosis
Objective:To investigate the effects of different doses of Tibolone combined with calcium amino acid chelate on bone fracture prevention,serum bone metabolism indexes and adipokines in postmenopausal osteoporosis.Methods:96 cases of postmenopausal osteoporosis selected 2020.1-2023.1 to our hospital,divided into group A,B and C,with 32 cases each.All three groups were treated for 6 months,and relevant indicators were compared.Results:There was no difference in the three groups during follow-up(P＞0.05).After treatment,bone density and serum CRTP 3 levels increased in the fracture group and the non-fracture group,while bone metabolism decreased,and the range of change in the non-fracture group was higher than that in the fracture group(P＜0.05).After the three groups,bone density level and serum CRTP 3 increased,bone metabolism index decreased,and the range of change in group B and C was higher than that in group A(P＜0.05),but there was no difference between groups B and C(P＞0.05).Incidence of adverse reactions group A＜B＜C(P＞0.05).Conclusion:Low dose tibolone combined with calcium amino acid chelate has better fracture prevention in postmenopausal osteoporosis patients,and the application is safe.
维普
万方数据