Effects of Different Doses of Tibolone Combined with Calcium Amino Acid Chelate on Bone Fracture Prevention,Serum Bone Metabolism Indexes and Adipokines in Postmenopausal Osteoporosis
Objective:To investigate the effects of different doses of Tibolone combined with calcium amino acid chelate on bone fracture prevention,serum bone metabolism indexes and adipokines in postmenopausal osteoporosis.Methods:96 cases of postmenopausal osteoporosis selected 2020.1-2023.1 to our hospital,divided into group A,B and C,with 32 cases each.All three groups were treated for 6 months,and relevant indicators were compared.Results:There was no difference in the three groups during follow-up(P＞0.05).After treatment,bone density and serum CRTP 3 levels increased in the fracture group and the non-fracture group,while bone metabolism decreased,and the range of change in the non-fracture group was higher than that in the fracture group(P＜0.05).After the three groups,bone density level and serum CRTP 3 increased,bone metabolism index decreased,and the range of change in group B and C was higher than that in group A(P＜0.05),but there was no difference between groups B and C(P＞0.05).Incidence of adverse reactions group A＜B＜C(P＞0.05).Conclusion:Low dose tibolone combined with calcium amino acid chelate has better fracture prevention in postmenopausal osteoporosis patients,and the application is safe.
万方数据
维普
