Changes in Cytokines before and after anti-VEGF Treatment for Polypoid Choroidal Vascular Disease and Analysis of Factors Affecting Short-term and Long-term Prognosis
Objective:To investigate the changes in cytokines before and after treatment with anti vascular endothelial growth factor(VEGF)in polypoid choroidal vascular lesions,as well as the factors affecting short-term and long-term prognosis.Methods:86 patients with polypoidal choroidal vascular lesions admitted to 2020.1-2023.1 were selected and treated with anti-VEGF and followed up for 12 months to compare relevant indicators.According to the follow-up results,the factors were divided into groups with recent BCVA,short-term BCVA,long-term BCVA and long-term BCVA.Results:VEGF,bFGF,IL-6,IL-8 and VCAM were lower than before and 3 months after treatment,IL-10 was higher than before and 3 months after treatment(P＜0.05);BCVA and CRT were lower than 12 months after treatment(P＜0.05);disease duration,GLD,bFGF,IL,IL-6,IL-8,IL-10 and VCAM were independent factors of long-term prognosis of polyp choroidal vasculopathy with anti-variable VE GF treatment(P＜0.05).Conclusion:Anti VEGF treatment for patients with polypoid choroidal vasculopathy can improve their visual acuity and CRT thickness.The concentrations of VEGF,bFGF,IL-6,IL-8,IL-10,and VCAM related cytokines in aqueous humor can undergo significant changes before and after treatment,and these cytokines can provide important reference value for predicting the short-and long-term prognosis of polypoid choroidal vasculopathy.
Polyp like choroidal vascular diseaseCytokinesVascular endothelial growth factorShort term and long-term prognosisInfluencing factors
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