摘要
目的:观察冠心病不稳定型心绞痛患者经血府逐瘀汤、尼可地尔联合治疗后,患者疗效及Toll样受体4(TLR4)/髓样分化因子88(MyD88)/核因子-κB(NF-κB)信号通路相关指标变化情况.方法:127例冠心病不稳定型心绞痛患者分为对照组(n=63,尼可地尔治疗)和研究组(n=64,血府逐瘀汤联合尼可地尔治疗).对比两组中医证候评分、心功能指标、血脂指标以及外周血单核细胞TLR4/MyD88/NF-κB信号通路的表达水平.结果:研究组治疗后胸闷、胸部疼痛、疼痛部位固定、气短、口干评分、总积分、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、TLR4信使核糖核酸(mRNA)、MyD88mRNA、NF-κBmRNA低于对照组,心输出量(CO)、每搏输出量(SV)、心脏指数(CI)、左室射血分数(LVEF)、高密度脂蛋白胆固醇(HDL-C)高于对照组(P＜0.05).结论:血府逐瘀汤联合尼可地尔治疗冠心病不稳定型心绞痛,可有效改善临床症状,促进心功能恢复,调节血脂水平,可能与调节TLR4/MyD88/NF-κB信号通路有关.
Abstract
Objective:To observe patients with unstable angina pectoris of coronary heart disease after combined treatment with xuefu zhuyu decoction and nicorandil,the efficacy of patients and the changes of Toll-like receptor 4(TLR4)/myeloid differentiation factor 88(MyD88)/nuclear factor-κB(NF-κB)signaling pathway relate indexes.Methods:127 patients with unstable angina pectoris of coronary heart disease were divided into control group(n=63,treated with nicorandil)and study group(n=64,treated with xuefu zhuyu decoction combine with nicorandil)according to the two-color ball method.The chinese medicine syndrome scores,cardiac function index,blood lipid index and the expression level of TLR4/MyD88/NF-κB signaling pathway in peripheral blood mononuclear cells were compared between two groups.Results:Chest tightness,chest pain,pain site fixation,shortness of breath,dry mouth score,total score,total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),TLR4 messenger ribonucleic acid(mRNA),MyD88 mRNA and NF-κB mRNA in study group were lower than those in control group after treatment,while cardiac output(CO),stroke volume(SV),cardiac index(CI),left ventricular ejection fraction(LVEF)and high density lipoprotein cholesterol(HDL-C)were higher than those in control group(P＜0.05).Conclusion:Xuefu zhuyu decoction combined with nicorandil in the treatment of unstable angina pectoris of coronary heart disease can effectively improve clinical symptoms,promote the recovery of cardiac function,and regulate blood lipid levels,which may be relate to the regulation of TLR4/MyD88/NF-κB signaling pathway.
维普
万方数据