Analysis the Efficacy and Mechanism of Xuefu Zhuyu Decoction Combined with Nicorandil in the Treatment of Unstable Angina Pectoris of Coronary Heart Disease Based on TLR4/MyD88/NF-κB Signaling Pathway
Objective:To observe patients with unstable angina pectoris of coronary heart disease after combined treatment with xuefu zhuyu decoction and nicorandil,the efficacy of patients and the changes of Toll-like receptor 4(TLR4)/myeloid differentiation factor 88(MyD88)/nuclear factor-κB(NF-κB)signaling pathway relate indexes.Methods:127 patients with unstable angina pectoris of coronary heart disease were divided into control group(n=63,treated with nicorandil)and study group(n=64,treated with xuefu zhuyu decoction combine with nicorandil)according to the two-color ball method.The chinese medicine syndrome scores,cardiac function index,blood lipid index and the expression level of TLR4/MyD88/NF-κB signaling pathway in peripheral blood mononuclear cells were compared between two groups.Results:Chest tightness,chest pain,pain site fixation,shortness of breath,dry mouth score,total score,total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),TLR4 messenger ribonucleic acid(mRNA),MyD88 mRNA and NF-κB mRNA in study group were lower than those in control group after treatment,while cardiac output(CO),stroke volume(SV),cardiac index(CI),left ventricular ejection fraction(LVEF)and high density lipoprotein cholesterol(HDL-C)were higher than those in control group(P＜0.05).Conclusion:Xuefu zhuyu decoction combined with nicorandil in the treatment of unstable angina pectoris of coronary heart disease can effectively improve clinical symptoms,promote the recovery of cardiac function,and regulate blood lipid levels,which may be relate to the regulation of TLR4/MyD88/NF-κB signaling pathway.
万方数据
维普
