Levels of Serum Ferritin,Homocysteine and Hydroxy-terminal Hydrolase Pantothenic Acid L1 Levels in Children with Febrile Seizures and Their Correlation Analysis
Objective:Study the changes in serum ferritin,Hcy,and UCHL-1 levels in children with febrile convulsions,and analyze the relationship between serum ferritin,Hcy,and UCHL-1 and the onset of febrile convulsions.Methods:A total of 160 hospitalized febrile children were admitted to 2021.1-2024.5,among which 80 febrile children developed febrile convulsions as the study group,and the remaining 80 children only had simple fever as the control group.Compare the relevant indicators and analyze the correlation and diagnostic value.Results:Serum ferritin was lower in the study group than in the control group,and serum Hcy,UCHL-1,IL-6,IL-1 β,TNF-α,and CRP were all higher than those in the control group(P＜0.05).Serum ferritin,Hcy,and UCHL-1 were positively correlated with serum inflammatory factors in children with febrile convulsions(P＜0.05).The ROC curve showed that serum ferritin,Hcy and UCHL-1 were 0.861,0.757 and 0.906,respectively,and the specifiicity and sensitivity of thermal convulsions were 81.65％and 79.23％,73.02％and 76.68％,89.35％and 88.79％,respectively.Conclusion:The level of serum ferritin in children with febrile seizures decreased,while the level of serum Hcy and UCHL-1 increased,and they are related to the level of peripheral blood inflammation in children with febrile seizures and can be used as biomarkers for diagnosing febrile seizures.
万方数据
维普
