弥漫性大B细胞淋巴瘤患者循环肿瘤DNA与PET-CT基线肿瘤参数动态变化及相关性研究

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中文摘要：目的:研究弥漫性大B细胞淋巴瘤患者的ctDNA与PET-CT基线肿瘤参数动态变化以及相关性。方法:将2020。1～2022。2血液科诊治的63例弥漫性大B细胞淋巴瘤患者为观察组，同期22例非肿瘤患者患者为对照组，测定并比较相关指标，并分析相关性。结果:观察组患者的ctDNA、SUVmax、SUVmean、TMTV、TLG高于对照组患者(P＜0。05);观察组内ctDNA、SUVmax、SUVmean、TMTV、TLG在Ann-Arbor分期中逐渐上升，在不同治疗时间段中逐渐下降(P＜0。05);Spearman相关性显示:cDNA与SUVmax、SUVmean、TMTV、TLG均呈正相关性(P＜0。05)。结论:弥漫性大B细胞淋巴瘤患者的ctDNA、PET-CT基线肿瘤参数均随着Ann-Arbor分期的上升而升高，化疗疗程的增加而下降，且ctDNA与SUVmax、SUVmean、TMTV、TLG呈正相关性。

外文标题：Dynamic Changes and Correlation between Circulating Tumor DNA and Tumor Parameters of PET-CT at Baseline in Patients with Diffuse Large B-cell Lymphoma

外文摘要：Objective:The dynamics and correlation of ctDNA and PET-CT baseline tumor parameters in patients with diffuse large B-cell lymphoma.Methods:63 patients with diffuse large B cell lymphoma treated by hematology department from 2020.1 to 2022.2 were in the observation group,and 22 non-tumor patients were in the matched group.Relevant indicators were determined and compared,and the correlation was analyzed.Result:The ctDNA,SUVmax,SUVmean,TMTV,and TLG were higher than those in the observation group(P＜0.05);ctDNA,SUVmax,SUVmean,TMTV,TLG gradually increased in Ann-Arbor stage and decreased in different treatment periods(P＜0.05);Spearman correlation showed positive cDNA with SUVmax,SUVmean,TMTV,and TLG(P＜0.05).Conclusion:The baseline tumor parameters of ctDNA and PET-CT in patients with diffuse large B-cell lymphoma increase with the increase of Ann Arbor stage,while decrease with the increase of chemotherapy course.ctDNA is positively correlated with SUVmax,SUVmean,TMTV,TLG.

外文关键词：

Diffuse Large B-cell LymphomaCirculating Tumor DNAPositron Emission Computed Tomography

作者：

郎涛、李雪国、翟顺生、王如民、徐艳芳、古再丽努尔·吾甫尔

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作者单位：

新疆维吾尔自治区人民医院血液病科新疆乌鲁木齐 830001

关键词：

弥漫性大B细胞淋巴瘤循环肿瘤DNA 正电子发射计算机断层显像

出版年：

2024

DOI：

10.13241/j.cnki.pmb.2024.23.041

现代生物医学进展

黑龙江省森工总医院哈尔滨医科大学附属第四医院

现代生物医学进展

CSTPCD

影响因子：0.755

ISSN：1673-6273

年,卷(期)：2024.24(23)