摘要
目的:研究弥漫性大B细胞淋巴瘤患者的ctDNA与PET-CT基线肿瘤参数动态变化以及相关性.方法:将2020.1～2022.2血液科诊治的63例弥漫性大B细胞淋巴瘤患者为观察组,同期22例非肿瘤患者患者为对照组,测定并比较相关指标,并分析相关性.结果:观察组患者的ctDNA、SUVmax、SUVmean、TMTV、TLG高于对照组患者(P＜0.05);观察组内ctDNA、SUVmax、SUVmean、TMTV、TLG在Ann-Arbor分期中逐渐上升,在不同治疗时间段中逐渐下降(P＜0.05);Spearman相关性显示:cDNA与SUVmax、SUVmean、TMTV、TLG均呈正相关性(P＜0.05).结论:弥漫性大B细胞淋巴瘤患者的ctDNA、PET-CT基线肿瘤参数均随着Ann-Arbor分期的上升而升高,化疗疗程的增加而下降,且ctDNA与SUVmax、SUVmean、TMTV、TLG呈正相关性.
Abstract
Objective:The dynamics and correlation of ctDNA and PET-CT baseline tumor parameters in patients with diffuse large B-cell lymphoma.Methods:63 patients with diffuse large B cell lymphoma treated by hematology department from 2020.1 to 2022.2 were in the observation group,and 22 non-tumor patients were in the matched group.Relevant indicators were determined and compared,and the correlation was analyzed.Result:The ctDNA,SUVmax,SUVmean,TMTV,and TLG were higher than those in the observation group(P＜0.05);ctDNA,SUVmax,SUVmean,TMTV,TLG gradually increased in Ann-Arbor stage and decreased in different treatment periods(P＜0.05);Spearman correlation showed positive cDNA with SUVmax,SUVmean,TMTV,and TLG(P＜0.05).Conclusion:The baseline tumor parameters of ctDNA and PET-CT in patients with diffuse large B-cell lymphoma increase with the increase of Ann Arbor stage,while decrease with the increase of chemotherapy course.ctDNA is positively correlated with SUVmax,SUVmean,TMTV,TLG.
维普
万方数据