Objective:To investigate the expression of Sine oculis homeobox homolog 2(Six2)in osteosarcoma and its relationship with clinical characteristics and prognosis.Method:A total of 54 patients with primary osteosarcoma collected were collected as the subjects of this study.Reverse Transcription-Polymerase Chain Reaction(RT-PCR),and immunohistochemistry were used to explore Six2 expression in osteosarcoma.Clinical information was collected and the relationship between Six2 and clinical characteristics of patients with osteosarcoma was.analyzed.Patients were followed up for 3 years,recording patient survival data information,and drawing survival analysis curves to explore the relationship between Six2 expression and osteosarcoma prognosis.Result:Six2 was highly expressed in both gene and protein levels in osteosarcoma tissues compared to adjacent normal tissues.The expression of Six2 was correlated with distant metastasis(P＜0.05).The higher the expression level of Six2,the worse the prognosis in osteosarcoma patients(P＜0.05).Conclusion:Six2 is highly expressed in osteosarcoma tissues and is associated with poor prognosis,which may be involved in the occurrence and development of osteosarcoma.
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