摘要
目的:探讨miR-592、miR155-5P及miR20a对肺癌远处转移的判定及预后预测价值.方法:选取2019.1-2022.1收治的100例肺癌患者,分为远处转移组、非远处转移组.检测各组miR-592、miR155-5P及miR20a表达水平并分析诊断价值.1年随访后分为预后不良组、预后良好组,对比资料,并分析预测价值.结果:远处转移组癌组织miR-592、miR155-5P及miR20a相对表达量高于非远处转移组(P＜0.05);miR-592、miR155-5P及miR20a三者联合对肺癌远处转移的诊断灵敏度、特异度高于三者单一诊断;预后良好组与预后不良组患者临床分期、远处转移、分化程度、miR-592、miR155-5P及miR20a相对表达量对比差异显著(P＜0.05);临床分期、远处转移、分化程度、miR-592、miR155-5P及miR20a对肺癌预后不良具有独立预测价值(P＜0.05).结论:miR-592、miR155-5P及miR20a三者结合对于肺癌远处转移的诊断灵敏度、特异度较高,且可对肺癌预后情况进行早期预测.
Abstract
Objective:To explore the determination and prognostic prediction value of miR-592,miR155-5P and miR20a for distant metastasis of lung cancer.Methods:A total of 100 lung cancer patients admitted to 2019.1-2022.1 were selected and divided into distant and non-distant metastasis groups.The expression levels of miR-592,miR155-5P and miR20a in each group were tested and analyzed for diagnostic value.After 1-year follow-up,it was divided into poor prognosis and good prognosis,data were compared and predictive value was analyzed.Results:The relative expression level of miR-592,miR155-5P and miR20a in the distant metastasis group was higher than that in the non-distant metastasis group(P＜0.05);The diagnostic sensitivity and specificity of miR-592,miR155-5P and miR20a for distant metastasis are higher than the single diagnosis of the three;The clinical stage,distant metastasis,differentiation,miR-592,miR1 55-5P and miR20a between the good prognosis and poor prognosis(P＜0.05);Clinical stage,distant metastasis,degree of differentiation,miR-592,miR155-5P and miR20a had independent predictive value for poor prognosis of lung cancer(P＜0.05).Conclusion:The combination of miR-592,miR155-5P and miR20a has high sensitivity and specificity for the diagnosis of distant metastasis of lung cancer patients,and can early predict the prognosis of lung cancer.
维普
万方数据