The Diagnostic and Prognostic Value of miR-592,miR155-5P,and miR20a in Distant Metastasis of Lung Cancer
Objective:To explore the determination and prognostic prediction value of miR-592,miR155-5P and miR20a for distant metastasis of lung cancer.Methods:A total of 100 lung cancer patients admitted to 2019.1-2022.1 were selected and divided into distant and non-distant metastasis groups.The expression levels of miR-592,miR155-5P and miR20a in each group were tested and analyzed for diagnostic value.After 1-year follow-up,it was divided into poor prognosis and good prognosis,data were compared and predictive value was analyzed.Results:The relative expression level of miR-592,miR155-5P and miR20a in the distant metastasis group was higher than that in the non-distant metastasis group(P＜0.05);The diagnostic sensitivity and specificity of miR-592,miR155-5P and miR20a for distant metastasis are higher than the single diagnosis of the three;The clinical stage,distant metastasis,differentiation,miR-592,miR1 55-5P and miR20a between the good prognosis and poor prognosis(P＜0.05);Clinical stage,distant metastasis,degree of differentiation,miR-592,miR155-5P and miR20a had independent predictive value for poor prognosis of lung cancer(P＜0.05).Conclusion:The combination of miR-592,miR155-5P and miR20a has high sensitivity and specificity for the diagnosis of distant metastasis of lung cancer patients,and can early predict the prognosis of lung cancer.
万方数据
维普
