Analysis of the Relationship between Aqueous Humor TNC,Sema3 A,MCP-1 and Postoperative Neovascular Glaucoma in Patients with Proliferative Diabetic Retinopathy
Analysis of the Relationship between Aqueous Humor TNC,Sema3 A,MCP-1 and Postoperative Neovascular Glaucoma in Patients with Proliferative Diabetic Retinopathy
Objective:To analyze the relationship between aqueous humor tenascin C(TNC),semaphorins 3A(Sema3A),monocyte chemoattractant protein-1(MCP-1)and postoperative neovascular glaucoma(NVG)in patients with proliferative diabetic retinopathy(PDR).Methods:240(300 eyes)patients with PDR were selected,all patients underwent vitrectomy.Patients were followed up for 1 year after operation,and they were divided into concurrent NVG group and non-concurrent NVG group according to whether NVG occurred or not.The levels of TNC,Sema3A and MCP-1 in aqueous humor were detected,the influencing factors of postoperative NVG in PDR patients were analyzed by multivariate logistic regression.Results:240(300 eyes)of PDR patients had NVG in 55 cases(79 eyes)at 1 year after operation,accounting for 26.33％.The levels of aqueous humor TNC,Sema3A and MCP-1 in concurrent NVG group were higher than those in non-concurrent NVG group(P＜0.05).Residual retinal perfusion zone,ipsilateral carotid artery stenosis＞25％,and elevated TNC,Sema3A,and MCP-1 levels were independent risk factors for postoperative NVG in patients with PDR(P＜0.05).Conclusion:The high expression of TNC,Sema3A and MCP-1 in aqueous humor are independent risk factor for postoperative NVG in PDR patients.
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