Changes and Clinical Significance of Serum SPP1,E-cadherin and STAT3 in Patients with Advanced Non-Small Cell Lung Cancer before and after Three-Dimensional Conformal Radiotherapy
Objective:To investigate the changes and clinical signifiicance of serum secreted phosphoprotein 1(SPP1),E-cadherin and signal transducer and activator of transcription 3(STAT3)levels in patients with advanced non-small cell lung cancer(NSCLC)before and after three-dimensional conformal radiotherapy.Methods:146 patients with advanced NSCLC were selected as NSCLC group,and 75 healthy people who underwent physical examination in our hospital during the same period were selected as control group.Patients were divided into effective group and ineffective group according to the efficacy.Patients with advanced NSCLC were followed up for 12 months,they were divided into survival group and death group according to the survival status.Results:The levels of serum SPP1 and STAT3 in NSCLC group before radiotherapy were higher than those in control group,and the level of serum E-cadherin was lower than that in control group(P＜0.05).The total effective rate of 146 patients with advanced NSCLC after radiotherapy was 47.95％(70/146).The serum SPP1 and STAT3 levels in ineffective group were higher than those in effective group before and after radiotherapy,and the serum E-cadherin level was lower than that in effective group(P＜0.05).The serum SPP1 and STAT3 levels in death group before radiotherapy were higher than those in survival group,and the serum E-cadherin level was lower than that in survival group(P＜0.05).Conclusion:The levels of serum SPP1 and STAT3 in patients with advanced NSCLC were highly expressed before radiotherapy,and the level of serum E-cadherin was low,the levels of serum SPP1 and STAT3 decreased after three-dimensional conformal radiotherapy,and the level of serum E-cadherin increased.
Advanced non-small cell lung cancerThree-dimensional conformal radiotherapySecreted phosphoprotein 1E-cadherinSignal transducer and activator of transcription 3
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维普
