Study on the Therapeutic Effect of Metronidazole Gel Combined with Terpinen-4-O1 on Demodex Blepharitis
Objective:To investigate the therapeutic effect of metronidazole gel combined with terpinen-4-ol on demodex blepharitis.Methods:100 patients(100 eyes)with demodex blepharitis were divided into control group and study group according to the random number table method,50 cases(50 eyes)in each group.Control group was treated with terpinen-4-ol cotton tablets,and study group was treated with metronidazole gel on the basis of control group.The changes of demodex mites microscopic examination counts,eye symptoms(itching,dryness,foreign body sensation,blurred vision)score,ocular surface related score[ocular surface disease index(OSDI)score,meibomian gland opening score],tear film stability index[tear film breakup time(BUT),corneal fluorescein staining(FL)score]were observed before and after treatment in two groups.Results:1 month after treatment and 3 months after treatment,the demodex mites microscopic examination counts in two groups decreased,and study group was lower than that of control group at the same time point(P＜0.05).1 month after treatment and 3 months after treatment,the scores of eye itching,dryness,foreign body sensation,blurred vision,OSDI,meibomian gland opening and FL in two groups decreased,and study group were lower than those of control group at the same time point(P＜0.05).1 month after treatment and 3 months after treatment,BUT increased,and study group was higher than that of control group at the same time point(P＜0.05).Conclusion:The curative effect of metronidazole gel combined with terpinen-4-ol in the treatment of demodex blepharitis is significant,which can strengthen the effect of mite removal,improve the stability of tear film and effectively reduce the eye symptoms of patients.
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