Effects of Wenfei Tongbi Decoction Combined with Methylprednisolone on Lung Function,Serum KL-6,HMGB-1,IL-18 Levels and Quality of Life in Patients with Interstitial Lung Disease
Objective:To investigate the effects of wenfei tongbi decoction combined with methylprednisolone on lung function,serum salivary liquefied sugar chain antigen-6(KL-6),high mobility group protein-1(HMGB-1),interleukin-18(IL-18)levels and quality of life in patients with interstitial lung disease(ILD).Methods:According to the random number table method,91 ILD patients admitted to Rugao Traditional Chinese Medicine Hospital from February 2022 to December 2023 were divided into control group(methylprednisolone treatment,n=45 cases)and observation group(wenfei tongbi decoction combined with methylprednisolone treatment,n=46 cases).The curative effect,the improvement time of clinical symptoms,lung function indexes[forced expiratory volume in the first second(FEV1),carbon monoxide diffusion volume as a percentage of predicted value(DLco％),forced vital capacity(FVC)],serum KL-6,HMGB-1,IL-18 levels,St.George's Respiratory Questionnaire(SGRQ)score and safety were compared between two groups.Results:Compared with control group,the improvement time of clinical symptoms and signs such as dyspnea,cough,dry and wet rales in observation group after treatment was shorter,and the total effective rate was higher(P＜0.05).Compared with control group,FVC,FEV1 and DLco％were higher in observation group after treatment,and serum KL-6,HMGB-1,IL-18 levels and SGRQ scores were lower(P＜0.05).The total incidence of adverse reactions in control group was 6.66％,and that in observation group was 8.69％,which was no difference between the two groups(P＞0.05).Conclusion:Wenfei tongbi decoction combined with methylprednisolone in the treatment of ILD,which can promote the improvement of clinical symptoms and lung function,regulate the levels of serum KL-6,HMGB-1 and IL-18,and improve the quality of life of patients.
Wenfei tongbi decoctionMethylprednisoloneInterstitial lung diseaseLung functionSalivary liquefied sugar chain antigen-6High mobility group protein-1Interleukin-18Quality of life
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维普
