Explore the Pathogenesis of Stroke Based on Mitochondrial Related Reactive Oxygen Species and Glutathione
Objective:To explore the role and clinical significance of mitochondria related reactive oxygen species(ROS)and glutathione(GSH)related genes in stroke based on bioinformatics,and to screen the key genes.Methods:Stroke related targets were obtained by gene expression omnibus(GEO)database,and mitochondria related ROS and GSH were obtained by FerrDb database.R language was used to evaluate the gene set scores and expression differences of mitochondria associated ROS and GSH related genes in stroke,as well as immune infiltration analysis,cluster analysis and post-cluster subgroup related feature differences.Results:The expression of mitochondrial related ROS and GSH gene sets was different between the normal group and the stroke group,and the expression levels of immune cells and inflammatory factors were significantly different between the two groups.Subgroup 1 and subgroup 2 were different in clinical phenotype,gene expression level,proportion of immune cells,level of inflammatory factors and protein enrichment.Conclusion:Mitochondria-related ROS and GSH genes play an important role in the immunity of stroke,and the different expression levels of their key genes may affect different immune pathways and clinical phenotypes.
万方数据
维普
