Study on the Relationship between Serum Interleukin-33/Growth Stimulating Expression Gene 2 Protein Axis Level and Postoperative Recurrence in Liver Cancer Patients
Objective:To analyze the relationship between serum interleukin-33/growth stimulating expression gene 2 protein axis level and postoperative recurrence in patients with liver cancer.Methods:278 liver cancer patients who were divided into recurrence group and non-recurrence group according to whether recurrence occurred 12 months after hepatectomy.Preoperative serum IL-33 and ST2 levels,as well as clinical data,were compared between the two groups.The factors that influence postoperative recurrence in liver cancer patients were also analyzed and the usefulness of serum IL-33 and ST2 levels in predicting postoperative recurrence in liver cancer patients.Results:The preoperative serum IL-33 and ST2 levels in recurrence group were higher than those in non-recurrence group(P＜0.05).Multivariate Logistic regression analysis showed that,the risk factors affecting postoperative recurrence of HCC patients included preop-erative serum Alpha-fetoprotein(AFP)level ≥400 ng/mL,portal vein tumor thrombus,lymph node metastasis,elevated serum IL-33 level and elevated serum ST2 level(OR＞1,P＜0.05).The receiver operating characteristic(ROC)curve showed that,the AUC of combined detection of serum IL-33 and ST2 was the highest.Conclusion:The up-regulation of serum IL-33/ST2 axis will increase the risk of post-operative recurrence in liver cancer patients,and the combined detection of serum IL-33 and ST2 predicts a higher net benefit of postop-erative recurrence in liver cancer patients.
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