Clinical Efficacy of Aidi Injection Combined with Carrelizumab in the Treatment of Advanced Non-small Cell Lung Cancer:A Prospective Single-center Randomized Controlled Trial
Objective:Based on prospective single-center randomized controlled trial,to investigate the clinical efficacy of aidi in-jection combined with carrelizumab in treatment of patients with advanced non-small cell lung cancer(NSCLC).Methods:A total of 82 patients with advanced NSCLC were divided into control group(n=41)and study group(n=41)by random number table method.Control group received conventional chemotherapy and carrelizumab treatment,and study group received aidi injection on the basis of control group.The objective response rate(ORR),disease control rate(DCR),serum tumor markers[cytokeratin 19 fragment antigen 21-1(CYFRA21-1),squamous cell carcinoma antigen(SCCA),tumor specific growth factor(TSGF)],immune indexes[immunoglobulin M(IgM),immunoglobulin A(IgA),immunoglobulin G(IgG),dendritic cells(DC)],tumor invasion and metastasis indexes[matrix metallo-proteinase 1(MMP-1),matrix metalloproteinase 2(MMP-2),matrix metalloproteinase 9(MMP-9)]and the total incidence of adverse re-actions were compared between two groups.Results:The ORR and DCR in study group were higher than those in control group(P＜0.05).The levels of serum CYFRA21-1,TSGF and SCCA in two groups decreased after treatment,and the levels of serum CYFRA21-1,TSGF and SCCA in study group were lower than those in control group(P＜0.05).IgM,IgA,IgG and DC decreased in both groups after treat-ment,and IgM,IgA,IgG and DC in study group were higher than those in control group(P＜0.05).The levels of serum MMP-1,MMP-9 and MMP-2 in two groups decreased after treatment,and the levels of serum MMP-1,MMP-9 and MMP-2 in study group were lower than those in control group(P＜0.05).There was no difference in the total incidence of adverse reactions in two groups(P＞0.05).Conclu-sion:Aidi injection combined with carrelizumab in the treatment of advanced NSCLC,which can improve the overall efficacy,effec-tively regulate the level of serum tumor markers,reduce immunosuppression,prevent tumor invasion and metastasis,and is safe and ef-fective.
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