Study on the Relationship between Serum Indole-2,3-dioxygenase with Anxiety,Depression and Traditional Chinese Medicine Syndromes Type in Diarrhea-predominant Irritable Bowel Syndrome
Objective:To study the relationship between serum indole-2,3-dioxygenase(IDO)with anxiety,depression and differ-ent traditional chinese medicine syndromes types in patients with diarrhea-predominant irritable bowel syndrome(IBS-D).Methods:121 IBS-D patients and 100 healthy volunteers who underwent physical examinations were selected as the control group.IBS-D patients were divided into IBS-D with depression group and IBS-D without depression group based on their depression status;and according to the anxiety status,they were divided into IBS-D with anxiety group and IBS-D without anxiety group.Detected serum IDO levels and calcu-lateed IDO activation index,and explore the relationship between IDO levels,IDO activation index,and different traditional chinese medicine syndrome types in IBS-D patients were analyze.Results:The serum IDO levels and IDO activation index of IBS-D group were higher than those of the control group(P＜0.05).The serum IDO levels and IDO activation index in the IBS-D with depression group were higher than those in the IBS-D without depression group(P＜0.05).The serum IDO levels and IDO activation index in the IBS-D with anx-iety group were higher than those in the IBS-D without anxiety group(P＜0.05).The serum IDO levels of liver stagnation and spleen defi-ciency type,spleen and stomach damp heat type,and spleen deficiency wet block type were higher than those of the control group(P＜0.05),and the IDO activation index of splenic kidney yang deficiency type,liver stagnation and spleen deficiency type,spleen deficiency wet block type and spleen and stomach damp heat type were higher than that of the control group(P＜0.05).The serum IDO level was posi-tively correlated with liver stagnation and spleen deficiency type,and negatively correlated with splenic kidney yang deficiency type and intestinal dryness-heat type(P＜0.05).The IDO activation index was positively correlated with liver stagnation and spleen deficiency type,and negatively correlated with intestinal dryness-heat type and spleen deficiency wet block type(P＜0.05).Conclusion:The elevated levels of serum IDO and IDO activation in IBS-D patients are related to their anxiety,depression,and traditional chinese medicine syndrome types.Serum IDO levels and activation levels can provide reference for clinical treatment of IBS-D based on syndrome differentiation.
Diarrhea-predominant irritable bowel syndromeTraditional chinese medicine syndromes typeIndole-2,3-dioxygenaseAnxiety and depression
NETL
NSTL
万方数据
