Relationship between Serum 25(OH)D,MCP-1,PTX3 Levels and Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease
Objective:To investigate the relationship between serum 25-hydroxyvitamin D[25(OH)D],monocyte chemoattrac-tant protein 1(MCP-1),pentraxin 3(PTX3)levels in patients with chronic obstructive pulmonary disease(COPD)and osteoporosis.Methods:182 COPD patients(COPD group)admitted to our hospital from December 2021 to November 2023 and 95 healthy individuals(control group)who underwent physical examination in our hospital during the same period were selected.COPD patients were divided into osteoporosis group and non-osteoporosis group based on the occurrence of osteoporosis.General information of COPD patients was collected,and the influencing factors of osteoporosis in patients with COPD were analyzed using univariate and multivariate Logistic regression analysis.Results:Serum 25(OH)D levels in control group,non-osteoporosis group and osteoporosis group were decreased successively,while serum MCP-1 and PTX3 levels were increased successively(P＜0.05).Multivariate Logistic regression analysis showed that advanced age,history of glucocorticoid use,low body mass index,smoking history,decreased serum level of 25(OH)D,and increased serum levels of MCP-1 and PTX3 are risk factors for osteoporosis in patients with COPD(P＜0.05).Conclusion:Decreased serum level of 25(OH)D and increased serum levels of MCP-1 and PTX3 jointly promote the progression of osteoporosis in patients with COPD.
Chronic obstructive pulmonary disease25-hydroxyvitamin DMonocyte chemoattractant protein 1Pentraxin 3Osteo-porosis
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