Study on the Relationship between Cerebrospinal Fluid Exosome miR-204-3p,Serum Exosome lncRNA SOX21-AS1 and Postoperative Recurrence in Patients with Brain Glioma
Objective:To analyze the expression of cerebrospinal fluid exosome microRNA-204-3p(miR-204-3p)and serum exo-some long-chain non-coding RNA cytokine signal transduction inhibitor 2-antisense transcript 1(lncRNA SOX21-AS1)in patients with brain glioma and their relationship with postoperative recurrence.Methods:207 patients with brain glioma were selected as brain glioma group,and 110 patients with craniocerebral injury were selected as craniocerebral injury group.patients were divided into recurrence group and non-recurrence group according to the postoperative recurrence.The influencing factors of postoperative recurrence in patients with brain glioma were analyzed by univariate analysis,and the risk factors affecting postoperative recurrence were analyzed by multi-variate Logistic regression analysis.Results:Follow followed up 6 months after operation,56 patients with brain glioma recurred,with a recurrence rate of 27.05％.Compared with craniocerebral injury group,the expression levels of cerebrospinal fluid exosome miR-204-3p and serum exosome lncRNA SOX21-AS1 in brain glioma group were significantly higher(P＜0.05).Tumor diameter≥5 cm,high-grade glioma,incomplete tumor resection,clinical stage Ⅲ-Ⅳ,high expression of miR-204-3p and high expression of lncRNA SOX21-AS1 were all risk factors for postoperative recurrence in patients with brain glioma(P＜0.05).Conclusion:The expression levels of cere-brospinal fluid exosome miR-204-3p and serum exosome lncRNA SOX21-AS1 in patients with brain glioma are significantly increased,and both are correlated with postoperative recurrence.
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