Randomized Controlled Study of Opioid-Free General Anesthesia Combined with Bilateral TAPB in Gynecological Laparoscopic Surgery
Objective:To observe the effect of opioid-free general anesthesia combined with bilateral transversus abdominis plane block(TAPB)in gynecological laparoscopic surgery.Methods:126 patients who needed gynecological laparoscopic surgery were divid-ed into single group(receiving total intravenous general anesthesia,n=63)and combined group(receiving opioid-free general anesthesia combined with bilateral TAPB,n=63)by using random number table method.The postoperative pain,sedation,recovery time after anes-thesia,depression,sleep improvement,postoperative nausea and vomiting,and application of antiemetic drugs were observed in two groups.Results:12 h and 24 h after operation,the visual analogue scale(VAS)scores in two groups increased,and the Ramsay sedation score decreased(P＜0.05).The VAS score in combined group was lower than that in single group at the same time,and the Ramsay seda-tion score was higher than that in single group at the same time(P＜0.05).The spontaneous breathing recovery time,recovery time and tracheal intubation removal time in combined group were shorter than those in single group(P＜0.05).7 d and 14 d after operation,the scores of Hamilton Depression Scale-17(HAMD-17)and Pittsburgh Sleep Quality Index(PSQI)in two groups decreased(P＜0.05),and the scores of HAMD-17 and PSQI in combined group were lower than those in single group at the same time(P＜0.05).The incidence of postoperative nausea and vomiting and the application of antiemetic drugs in combined group were lower than those in single group(P＜0.05).Conclusion:Opioid-free general anesthesia combined with bilateral TAPB has a good effect in gynecological laparoscopic surgery,which can significantly calm and relieve pain,promote postoperative recovery,improve postoperative depression and sleep qual-ity,and has good safety.
Opioid-freeTransversus abdominis plane blockGeneral anesthesiaGynecological laparoscopic surgery
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